The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors
Open accessAbstract
The MEROPS database (http://merops.sanger.ac.uk) is an integrated source of information about peptidases, their substrates and inhibitors, which are of great relevance to biology, medicine and biotechnology. The hierarchical classification of the database is as follows: homologous sets of sequences are grouped into a protein species; protein species are grouped into a family; families are grouped into clans. There is a type example for each protein species (known as a 'holotype'), family and clan, and each protein species, family and clan has its own unique identifier. Pages to show the involvement of peptidases and peptidase inhibitors in biological pathways have been created. Each page shows the peptidases and peptidase inhibitors involved in the pathway, along with the known substrate cleavages and peptidase-inhibitor interactions, and a link to the KEGG database of biological pathways. Links have also been established with the IUPHAR Guide to Pharmacology. A new service has been set up to allow the submission of identified substrate cleavages so that conservation of the cleavage site can be assessed. This should help establish whether or not a cleavage site is physiologically relevant on the basis that such a cleavage site is likely to be conserved.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Pfam: the protein families database
Finn, R. D., Bateman, A., Clements, J., Coggill, P., Eberhardt, R. Y., Eddy, S. R., Heger, A., Hetherington, K., Holm, L., Mistry, J., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1223 · Cited by 6,148
Self-citationKEGG for integration and interpretation of large-scale molecular data sets
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., & Tanabe, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr988 · Cited by 4,848
UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches
Suzek, B. E., Wang, Y., Huang, H., McGarvey, P. B., Wu, C. H., & the UniProt Consortium (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu739 · Cited by 1,928
Evolutionary families of peptidases
Rawlings, N. D., & Barrett, A. J. (1993) · Biochemical Journal · doi:10.1042/bj2900205 · Cited by 923
Self-citationPawson, A. J., Sharman, J. L., Benson, H. E., Faccenda, E., Alexander, S. P. H., Buneman, O. P., Davenport, A. P., McGrath, J. C., Peters, J. A., Southan, C., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1143 · Cited by 849
MEROPS: the peptidase database
Rawlings, N. D., & Barrett, A. J. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.325 · Cited by 793
Self-citationEvolutionary families of peptidase inhibitors
RAWLINGS, N. D., TOLLE, D. P., & BARRETT, A. J. (2004) · Biochemical Journal · doi:10.1042/bj20031825 · Cited by 618
Self-citationMEROPS: the peptidase database
Rawlings, N. D., Morton, F. R., Kok, C. Y., Kong, J., & Barrett, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm954 · Cited by 520
Self-citation
Cited by
Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities
Chakrabarti, S., Guha, S., & Majumder, K. (2018) · Nutrients · doi:10.3390/nu10111738 · Cited by 699
Isolation of an archaeon at the prokaryote–eukaryote interface
Imachi, H., Nobu, M. K., Nakahara, N., Morono, Y., Ogawara, M., Takaki, Y., Takano, Y., Uematsu, K., Ikuta, T., Ito, M., et al. (2020) · Nature · doi:10.1038/s41586-019-1916-6 · Cited by 624
New advances in the biodegradation of Poly(lactic) acid
Qi, X., Ren, Y., & Wang, X. (2017) · International Biodeterioration & Biodegradation · doi:10.1016/j.ibiod.2017.01.010 · Cited by 462
The fate of organic carbon in marine sediments - New insights from recent data and analysis
LaRowe, D. E., Arndt, S., Bradley, J. A., Estes, E. R., Hoarfrost, A., Lang, S. Q., Lloyd, K. G., Mahmoudi, N., Orsi, W. D., Shah Walter, S. R., et al. (2020) · Earth-Science Reviews · doi:10.1016/j.earscirev.2020.103146 · Cited by 298
Zhou, Z., Tran, P. Q., Kieft, K., & Anantharaman, K. (2020) · The ISME Journal · doi:10.1038/s41396-020-0669-4 · Cited by 282
Metadata
- Authors
- Rawlings, N. D., Barrett, A. J., & Finn, R.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-11-02
- Volume
- 44
- Issue
- D1
- Pages
- D343-D350
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1953569147
- Cited by
- 687
- References
- 26
- FWCI
- 31.99
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors. https://app.cochat.ai/papers/10.1093/nar/gkv1118
- The paper
- Rawlings, N. D., Barrett, A. J., & Finn, R. (2016). Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Research. https://doi.org/10.1093/nar/gkv1118
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
