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Cited by 326

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The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold

Open access
Knott, Gavin J., Bond, Charles S., Fox, Archa H.·2016·Nucleic Acids Research

Abstract

Nuclear proteins are often given a concise title that captures their function, such as 'transcription factor,' 'polymerase' or 'nuclear-receptor.' However, for members of the Drosophila behavior/human splicing (DBHS) protein family, no such clean-cut title exists. DBHS proteins are frequently identified engaging in almost every step of gene regulation, including but not limited to, transcriptional regulation, RNA processing and transport, and DNA repair. Herein, we present a coherent picture of DBHS proteins, integrating recent structural insights on dimerization, nucleic acid binding modalities and oligomerization propensity with biological function. The emerging paradigm describes a family of dynamic proteins mediating a wide range of protein-protein and protein-nucleic acid interactions, on the whole acting as a multipurpose molecular scaffold. Overall, significant steps toward appreciating the role of DBHS proteins have been made, but we are only beginning to understand the complexity and broader importance of this family in cellular biology.

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Metadata

Authors
Knott, G. J., Bond, C. S., & Fox, A. H.
Venue
Nucleic Acids Research
Published
2016-04-15
Volume
44
Issue
9
Pages
3989-4004
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2340295145
Cited by
326
References
160
FWCI
8.43
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. https://app.cochat.ai/papers/10.1093/nar/gkw271
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Knott, G. J., Bond, C. S., & Fox, A. H. (2016). The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. Nucleic Acids Research. https://doi.org/10.1093/nar/gkw271

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