The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
i-Motif DNA: structural features and significance to cell biology
Open accessAbstract
The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine base pairs (C:C+). First observed 25 years ago, and considered by many as a mere structural oddity, interest in and discussion on the biological role of i-motifs have grown dramatically in recent years. In this review we focus on structural aspects of i-motif formation, the factors leading to its stabilization and recent studies describing the possible role of i-motifs in fundamental biological processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Dysregulated pH: a perfect storm for cancer progression
Webb, B. A., Chimenti, M., Jacobson, M. P., & Barber, D. L. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3110 · Cited by 2,237
Quantitative visualization of DNA G-quadruplex structures in human cells
Biffi, G., Tannahill, D., McCafferty, J., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1548 · Cited by 2,146
Sen, D., & Gilbert, W. (1988) · Nature · doi:10.1038/334364a0 · Cited by 1,836
A tetrameric DNA structure with protonated cytosine-cytosine base pairs
Gehring, K., Leroy, J.-L., & Guéron, M. (1993) · Nature · doi:10.1038/363561a0 · Cited by 1,239
A DNA nanomachine that maps spatial and temporal pH changes inside living cells
Modi, S., M. G., S., Goswami, D., Gupta, G. D., Mayor, S., & Krishnan, Y. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.83 · Cited by 745
Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid
Watson, J. D., & Crick, F. H. C. (2004) · Resonance · doi:10.1007/bf02834980 · Cited by 656
Biffi, G., Di Antonio, M., Tannahill, D., & Balasubramanian, S. (2014) · Nature Chemistry · doi:10.1038/nchem.1805 · Cited by 606
Burger, A. M., Dai, F., Schultes, C. M., Reszka, A. P., Moore, M. J., Double, J. A., & Neidle, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2910 · Cited by 587
I-motif DNA structures are formed in the nuclei of human cells
Zeraati, M., Langley, D. B., Schofield, P., Moye, A. L., Rouet, R., Hughes, W. E., Bryan, T. M., Dinger, M. E., & Christ, D. (2018) · Nature Chemistry · doi:10.1038/s41557-018-0046-3 · Cited by 569
Cited by
The Structure and Function of DNA G-Quadruplexes
Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920
“Intercalatedmotif (i-motif) structures can be formed via stacks of intercalating hemiprotonated C-neutral C base pairs (C:C), and are generally stabilised in slightly acidic pH [112].”
BackgroundPolymeric DNA hydrogel: Design, synthesis and applications
Li, F., Tang, J., Geng, J., Luo, D., & Yang, D. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101163 · Cited by 308
Prediction of DNA i-motifs via machine learning
Yang, B., Guneri, D., Yu, H., Wright, E. P., Chen, W., Waller, Z. A. E., & Ding, Y. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae092 · Cited by 29
Metadata
- Authors
- Abou Assi, H., Garavís, M., González, C., & Damha, M. J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-16
- Volume
- 46
- Issue
- 16
- Pages
- 8038-8056
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2886466753
- Cited by
- 423
- References
- 77
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: i-Motif DNA: structural features and significance to cell biology. https://app.cochat.ai/papers/10.1093/nar/gky735
- The paper
- Abou Assi, H., Garavís, M., González, C., & Damha, M. J. (2018). i-Motif DNA: structural features and significance to cell biology. Nucleic Acids Research. https://doi.org/10.1093/nar/gky735
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
