The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
Open accessAbstract
Following extensive evidence for the formation of four-stranded DNA G-quadruplex structures in vitro, DNA G-quadruplexes have been observed within human cells. Although chemically distinct, RNA can also fold in vitro into G-quadruplex structures that are highly stable because of the 2'-hydroxyl group. However, RNA G-quadruplexes have not yet been reported in cells. Here, we demonstrate the visualization of RNA G-quadruplex structures within the cytoplasm of human cells using a G-quadruplex structure-specific antibody. We also demonstrate that small molecules that bind to G-quadruplexes in vitro can trap endogenous RNA G-quadruplexes when applied to cells. Furthermore, a small molecule that exhibits a preference for RNA G-quadruplexes rather than DNA G-quadruplexes in biophysical experiments also shows the same selectivity within a cellular context. Our findings provide substantive evidence for RNA G-quadruplex formation in the human transcriptome, and corroborate the selectivity and application of stabilizing ligands that target G-quadruplexes within a cellular context.
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Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Kumari, S., Bugaut, A., Huppert, J. L., & Balasubramanian, S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio864 · Cited by 822
Self-citationSmall-molecule–induced DNA damage identifies alternative DNA structures in human genes
Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.780 · Cited by 741
Self-citationRodriguez, R., Müller, S., Yeoman, J. A., Trentesaux, C., Riou, J.-F., & Balasubramanian, S. (2008) · Journal of the American Chemical Society · doi:10.1021/ja805615w · Cited by 517
Self-citationThe fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471
G-quadruplex RNA structure as a signal for neurite mRNA targeting
Subramanian, M., Rage, F., Tabet, R., Flatter, E., Mandel, J., & Moine, H. (2011) · The EMBO Reports · doi:10.1038/embor.2011.76 · Cited by 250
Cited by
G-quadruplex structures mark human regulatory chromatin
Hänsel-Hertsch, R., Beraldi, D., Lensing, S. V., Marsico, G., Zyner, K., Parry, A., Di Antonio, M., Pike, J., Kimura, H., Narita, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3662 · Cited by 964
Self-citationG-quadruplex unwinding helicases and their function in vivo
Sauer, M., & Paeschke, K. (2017) · Biochemical Society Transactions · doi:10.1042/bst20170097 · Cited by 179
Advances and challenges in identifying and characterizing G-quadruplex–protein interactions
Dai, Y., Teng, X., Zhang, Q., Hou, H., & Li, J. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.06.007 · Cited by 46
Metadata
- Authors
- Biffi, G., Di Antonio, M., Tannahill, D., & Balasubramanian, S.
- Venue
- Nature Chemistry
- Published
- 2013-11-24
- Volume
- 6
- Issue
- 1
- Pages
- 75-80
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2108763751
- Cited by
- 606
- References
- 6
- FWCI
- 20.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Biffi, G., Di Antonio, M., Tannahill, D., & Balasubramanian, S. (2014). Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells. Nature Chemistry. https://doi.org/10.1038/nchem.1805
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