The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Whole genome experimental maps of DNA G-quadruplexes in multiple species
Open accessAbstract
Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these secondary structures play in various organisms. Herein, we employ an improved version of a G-quadruplex sequencing method (G4-seq) to generate whole genome G4 maps for 12 species that include widely studied model organisms and also pathogens of clinical relevance. We identify G4 structures that form under physiological K+ conditions and also G4s that are stabilized by the G4-targeting small molecule pyridostatin (PDS). We discuss the various structural features of the experimentally observed G-quadruplexes (OQs), highlighting differences in their prevalence and enrichment across species. Our study describes diversity in sequence composition and genomic location for the OQs in the different species and reveals that the enrichment of OQs in gene promoters is particular to mammals such as mouse and human, among the species studied. The multi-species maps have been made publicly available as a resource to the research community. The maps can serve as blueprints for biological experiments in those model organisms, where G4 structures may play a role.
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“absent in the other organisms studied [52].”
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Landscape of G-quadruplex DNA structural regions in breast cancer
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Self-citationDynamic alternative DNA structures in biology and disease
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Metadata
- Authors
- Marsico, G., Chambers, V. S., Sahakyan, A. B., McCauley, P., Boutell, J. M., Antonio, M. D., & Balasubramanian, S.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-03-20
- Volume
- 47
- Issue
- 8
- Pages
- 3862-3874
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2923522997
- Cited by
- 431
- References
- 52
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- Marsico, G., Chambers, V. S., Sahakyan, A. B., McCauley, P., Boutell, J. M., Antonio, M. D., & Balasubramanian, S. (2019). Whole genome experimental maps of DNA G-quadruplexes in multiple species. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz179
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