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Cited by 309

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Impedance-based detection of DNA sequences using a silicon transducer with PNA as the probe layer

Open access
Macanovic, A.·2004·Nucleic Acids Research
DOI 10.1093/nar/gnh003
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Abstract

Electrochemical impedance measurements were used for the detection of single-strand DNA sequences using a peptide nucleic acid (PNA) probe layer immobilized onto Si/SiO2 chips. An epoxysilane layer is first immobilized onto the Si/SiO2 surface. The immobilization procedure consists of an epoxide/amine coupling reaction between the amino group of the PNA linker and the epoxide group of the silane. A 20-nucleotide sequence of PNA was used. Impedance measurements allow for the detection of the changes in charge distribution at the oxide/solution interface following modifications to the oxide surface. Due to these modifications, there are significant shifts in the semiconductor's flat-band potential after immobilization and hybridization. The results obtained using this direct and rapid approach are supported by fluorescence measurements according to classical methods for the detection of nucleic acid sequences.

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Metadata

Authors
Macanovic, A.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2004-01-21
Volume
32
Issue
2
Pages
20e-20
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/gnh003
OpenAlex
W2165347905
Cited by
309
References
1
FWCI
6.89
Type
journal article
Language
en
Open access
bronze

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