Left ventricular alterations and end‐stage renal disease
Abstract
The prevalence of left ventricular (LV) changes, especially LV hypertrophy (LVH), is high among patients with chronic kidney disease and end-stage renal disease (ESRD). Ventricular enlargement usually is associated with normal systolic function and increased stroke and cardiac index. In the absence of intrinsic heart disease, LV enlargement is most probably attributable to chronic volume/flow overload associated with anaemia, the presence of arteriovenous shunts, and sodium and water retention. In ESRD patients, hypertension is also a leading cause of LVH, but structural LV changes and myocardial fibrosis may also be due to non-haemodynamic factors such as angiotensin II, parathyroid hormone, endothelin, aldosterone, increased sympathetic nerve discharge and increased plasma catecholamines. To improve the clinical outcomes in ESRD, it is essential to prevent LVH and its complications by correcting the factors that contribute to flow and pressure overload, including anaemia.
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Under chronic anemic conditions, adjustments that initially increase cardiac output lead to left ventricular enlargement and eccentric left ventricular hypertrophy.
“Under chronic anemic conditions, adjustments that initially increase cardiac output lead to left ventricular enlargement and eccentric left ventricular hypertrophy (112).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [112]
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Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469 · see citing works
- Authors
- London, G. M.
- Affiliations
- Centre Hospitalier Frèderic-Henri Manhès (FR)
- Corresponding author
- London, Gerard M.
- ORCID
- London, Gerard M.
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01-01
- Volume
- 17
- Issue
- suppl_1
- Pages
- 29-36
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2109011321
- Cited by
- 229
- References
- 48
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 4 · 2023: 12 · 2022: 11 · 2021: 12 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 5 · 2013: 14 · 2012: 15
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- left ventricular hypertrophy, end-stage renal disease, chronic kidney disease, left ventricular dilatation, fluid overload, anemia, arteriovenous shunt, sodium and water retention, hypertension, myocardial fibrosis, angiotensin II, parathyroid hormone, endothelin, aldosterone, sympathetic nervous system, catecholamines, left ventricular function
- MeSH terms
- Hemodynamics, Humans, Hypertension, Kidney Failure, Chronic, Hypertrophy, Left Ventricular
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