Dietary plant and animal protein intake and decline in estimated glomerular filtration rate among elderly women: a 10-year longitudinal cohort study
Open accessAbstract
Background: Many older women demonstrate an age-related accelerating rate of renal decline that is associated with increased rates of bone disease, cardiovascular disease and mortality. Population-based protein restriction has been studied principally in patients with reduced renal function. In this investigation, we examined the hypothesis of a differential effect of plant-derived protein compared with animal-derived protein on renal function in older women. Methods: We assessed dietary intake from a validated food frequency questionnaire and the estimated glomerular filtration rate (eGFR) (using the Chronic Kidney Disease Epidemiology Collaboration creatinine and cystatin C equation) at baseline, 5 and 10 years in the Longitudinal Study of Aging Women cohort. We tested the association between plant- and animal-sourced protein intake and kidney function using linear mixed modeling. Results: A total of 1374 Caucasian women [mean (standard deviation, SD) age = 75 years (2.7) and mean (SD) baseline eGFR = 65.6 mL/min/1.73 m2 (13.1)] contributed to the analysis. The average decline in eGFR was 0.64 mL/min/1.73 m2/year [95% confidence interval (CI) 0.56–0.72]. Higher intakes of plant-sourced protein were associated with slower declines in eGFR after adjusting for covariates including animal protein and energy intake (P = 0.03). For each 10 g of plant protein, the yearly decline in eGFR was reduced by 0.12 mL/min/1.73 m2 (95% CI 0.01–0.23), principally associated with fruit-, vegetable- and nut-derived protein. The intake of animal protein was not associated with eGFR decline (P = 0.84). Conclusions: Older women consuming a diet that is richer in plant-sourced protein have a slower decline in kidney function. These data extend support for the health benefits of plant-rich diets in the general population to maintain kidney health.
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Greater consumption of plant protein is related to slower declines in eGFR in older women.
“Greater consumption of plant protein was related to slower declines in eGFR”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [95]
Intake of animal protein is not associated with kidney function decline in older women.
“intake of animal protein was not associated with kidney function decline [95].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [95]
Recent epidemiological evidence suggests that not only the amount of protein, but also the origin of protein (e.g., plant vs. animal), may be a factor that influences kidney function.
“Recent epidemiological evidence suggests that not only the amount of protein, but also the origin of protein (e.g., plant vs. animal), may be a factor that influences kidney function [95].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [95]
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Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594 · see citing works
- Authors
- Bernier-Jean, A., Prince, R. L., Lewis, J. R., Craig, J. C., Hodgson, J. M., Lim, W. H., Teixeira-Pinto, A., & Wong, G.
- Affiliations
- The University of Sydney (AU)
- The University of Western Australia (AU)
- Edith Cowan University (AU)
- Corresponding author
- Bernier-Jean, Amélie
- ORCID
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-05-26
- Volume
- 36
- Issue
- 9
- Pages
- 1640-1647
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2990488542
- Cited by
- 52
- References
- 32
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 2
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- Nephrology
- Funders
- Healthway Health Promotion Foundation of Western Australia (6018 1998 2000)
- National Health and Medical Research Council of Australia (254627, 303169)
- Fond de Recherche du Québec en Santé (#35837)
- National Health and Medical Research Council (GNT1151246)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- plant proteins, animal protein, protein intake, estimated glomerular filtration rate, renal function decline, renal function, older women, aging, plant-based diet, nut proteins, cystatin C
- MeSH terms
- Animal Proteins, Dietary, Aged, Diet, Female, Glomerular Filtration Rate, Humans, Longitudinal Studies, Risk Factors, Plant Proteins, Dietary, Cohort Studies
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