Erythropoietin ameliorates renal dysfunction during endotoxaemia
Abstract
BACKGROUND: Sepsis has a high mortality (50-80%) when associated with acute renal failure (ARF). Oxidant injury and proinflammatory cytokines and chemokines have been shown to increase with endotoxaemia-related ARF. Since erythropoietin (EPO) has been demonstrated to possess anti-oxidant and anti-inflammatory properties, EPO may have therapeutic efficacy for treating ARF associated with endotoxaemia. METHODS: Wild-type mice were given 2.5 mg/kg of intraperitoneal (i.p.) endotoxin, lipopolysaccharide (LPS), and studied 16 h later. Thirty minutes prior to LPS, the mice were given either EPO or vehicle. RESULTS: During endotoxaemia, EPO was found to significantly attenuate the renal dysfunction, as assessed by glomerular filtration rate (48.1 +/- 12.4 microl/min vs 136.7 +/- 30.2, P < 0.05). Renal blood flow and mean arterial pressure were not significantly different between the two groups. The renal dysfunction during endotoxaemia was associated with a decrease in renal superoxide dismutase (SOD). The EPO-related renal protection was associated with reversal of the effects of endotoxin on renal SOD. CONCLUSION: This is the first demonstration of a renal protective effect of EPO on endotoxin-related renal dysfunction.
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There is evidence that erythropoietin can help maintain superoxide dismutase activity, invoke haem oxygenase, remove poorly liganded iron, and interact with hydroxyl radical directly.
“There is evidence that it can help maintain superoxide dismutase activity [2214,2227], invoke haem oxygenase [2228], and in particular – from the perspective of this review – that it may remove poorly liganded iron [2229] and interact with hydroxyl radical directly [2230-2233].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [2214]
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- Authors
- Mitra, A., Bansal, S., Wang, W., Falk, S., Zolty, E., & Schrier, R. W.
- Affiliations
- University of Colorado Health (US)
- ORCID
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03-29
- Volume
- 22
- Issue
- 8
- Pages
- 2349-2353
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2148657070
- Cited by
- 56
- References
- 29
- Citations by year
- 2021: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 10
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- erythropoietin, endotoxemia, lipopolysaccharide, acute kidney injury, sepsis, renal dysfunction, superoxide dismutase, oxidative stress, anti-inflammatory activity, renal protection
- MeSH terms
- Animals, Erythropoietin, Glomerular Filtration Rate, Inflammation, Kidney, Kidney Diseases, Lipopolysaccharides, Male, Mice, Inbred C57BL, Nitric Oxide, Tumor Necrosis Factor-alpha, Cytokines, Sepsis, Endotoxemia, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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