The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Weight loss and proteinuria: systematic review of clinical trials and comparative cohorts
Abstract
BACKGROUND: Obesity is a risk factor for the progression of chronic kidney disease (CKD). The impact of weight loss on proteinuria and renal function is less clear. We aimed to determine the effect of intentional weight loss on proteinuria and kidney function. METHODS: Three bibliographic databases including Medline, Cochrane and SCUPOS as well as reference list of articles were searched. We included randomized and non-randomized controlled trials as well as single-arm trials published in English through May 2009 which examined urinary protein among obese or overweight adults before and after weight loss interventions including dietary restriction, exercise, anti-obesity medications and bariatric surgery. Study characteristics and methodological quality of trials were assessed. RESULTS: Five hundred twenty-two subjects from five controlled and eight uncontrolled trials were included. Weight loss interventions were associated with decreased proteinuria and microalbuminuria by 1.7 g [95% confidence interval (95% CI), 0.7 to 2.6 g] and 14 mg (95% CI, 11 to 17 mg), respectively (P < 0.05). Meta-regression showed that, independent of decline in mean arterial pressure, each 1 kg weight loss was associated with 110 mg (95% CI, 60 to 160 mg, P < 0.001) decrease in proteinuria and 1.1 mg (95% CI, 0.5 to 2.4 mg, P = 0.011) decrease in microalbuminuria, respectively. The decrease was observed across different designs and methods of weight loss. Only bariatric surgery resulted in a significant decrease in creatinine clearance. CONCLUSIONS: Weight loss is associated with decreased proteinuria and microalbuminuria. There were no data evaluating the durability of this decrease or the effect of weight loss on CKD progression.
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Cites
Estimating effect sizes from pretest-posttest-control group designs
Morris, S. B. (2008) · Organizational Research Methods · doi:10.1177/1094428106291059 · Cited by 2,133
The relationship between obesity and mortality in patients with heart failure
Horwich, T. B., Fonarow, G. C., Hamilton, M. A., MacLellan, W. R., Woo, M. A., & Tillisch, J. H. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01448-6 · Cited by 867
Functional and Structural Changes in the Kidney in the Early Stages of Obesity
HENEGAR, J. R., BIGLER, S. A., HENEGAR, L. K., TYAGI, S. C., & HALL, J. E. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1261211 · Cited by 549
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Lissin, L. W., Gauri, A. J., Froelicher, V. F., Ghayoumi, A., Myers, J., & Giacommini, J. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.126812 · Cited by 94 · cited 1×
“However, the increased mortality in such entities are often reported through observational studies which have not been able to distinguish intentional from unintentional weight loss or ignored adequate adjustments by chronicity or severity of underlying illnesses [48–51], sending controversial massages about the benef…”
BackgroundThe Paradox of Obesity in Patients with Heart Failure
Hall, J. A., French, T. K., Rasmusson, K. D., Vesty, J. C., Roberts, C. A., Rimmasch, H. L., Kfoury, A. G., & Renlund, D. G. (2005) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2005.00084.x · Cited by 46
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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D'Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman-Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 716
Obesity, hypertension, and chronic kidney disease
Hall, J., Juncos, L., Wang, Z., Hall, M., do Carmo, J., & da Silva, A. (2014) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s39739 · Cited by 520
Garofalo, C., Borrelli, S., Minutolo, R., Chiodini, P., De Nicola, L., & Conte, G. (2017) · Kidney International · doi:10.1016/j.kint.2016.12.013 · Cited by 363
Floege, J., Barbour, S. J., Cattran, D. C., Hogan, J. J., Nachman, P. H., Tang, S. C. W., Wetzels, J. F. M., Cheung, M., Wheeler, D. C., Winkelmayer, W. C., et al. (2019) · Kidney International · doi:10.1016/j.kint.2018.10.018 · Cited by 263
Metadata
- Authors
- Afshinnia, F., Wilt, T. J., Duval, S., Esmaeili, A., & Ibrahim, H. N.
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-11-27
- Volume
- 25
- Issue
- 4
- Pages
- 1173-1183
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2128639723
- Cited by
- 239
- References
- 6
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Afshinnia, F., Wilt, T. J., Duval, S., Esmaeili, A., & Ibrahim, H. N. (2010). Weight loss and proteinuria: systematic review of clinical trials and comparative cohorts. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfp640
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
