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Tribulus terrestris-induced severe nephrotoxicity in a young healthy male
Abstract
Herbal medications are being progressively utilized all over the world. Nevertheless, herbal remedies are not without hazards and several cases of adverse reactions have been described. Tribulus terrestris is traditionally used because of its aphrodisiac and antiurolithiatic activities with almost complete inhibition of stone formation. We report a case of T. terrestris-induced hepatotoxicity, nephrotoxicity and neurotoxicity in an Iranian male patient who used the plant's extract to prevent kidney stone formation. He presented with seizure and very high serum aminotransferases and creatinine after consuming herbal water for 2 days. Discontinuation of the herbal remedy resulted in improvement in symptoms and normalization of his liver enzymes.
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Metadata
- Authors
- Talasaz, A. H., Abbasi, M.-R., Abkhiz, S., & Dashti-Khavidaki, S.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Imam Khomeini Hospital (IR)
- Corresponding author
- Talasaz, A. H.
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-28
- Volume
- 25
- Issue
- 11
- Pages
- 3792-3793
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2121597109
- Cited by
- 62
- References
- 8
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Plant Toxicity and Pharmacological Properties
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- Tribulus terrestris, nephrotoxicity, hepatotoxicity, neurotoxicity, herbal medicine adverse effects, kidney stones, seizures, elevated liver enzymes, creatinine, healthy young men
- MeSH terms
- Adult, Creatinine, Humans, Male, Tribulus, Chemical and Drug Induced Liver Injury, Acute Kidney Injury
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