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Transforming growth factor- and the progression of renal disease
Abstract
Transforming growth factor-β (TGF-β) is a profibrotic cytokine found in chronic renal diseases, which initiates and modulates a variety of pathophysiological processes. It is synthesized by many renal cell types and exerts its biological functions through a variety of signalling pathways, including the Smad and MAPK pathways. In renal diseases, TGF-β is upregulated and induces renal cells to produce extracellular matrix proteins leading to glomerulosclerosis as well as tubulointerstitial fibrosis. Different types of renal cells undergo different pathophysiological changes induced by TGF-β, leading to apoptosis, hypertrophy and abnormalities of podocyte foot processes, which ultimately result in renal dysfunction. In this review, we describe the effects of TGF-β on different renal cell types and the means by which TGF-β participates in the pathomechanisms of glomerular and tubulointerstitial diseases.
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Cited by
TGF-β/Smad signaling in renal fibrosis
Meng, X.-M., Tang, P. M.-K., Li, J., & Lan, H. Y. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00082 · Cited by 666
AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms
He, L., Wei, Q., Liu, J., Yi, M., Liu, Y., Liu, H., Sun, L., Peng, Y., Liu, F., Venkatachalam, M. A., et al. (2017) · Kidney International · doi:10.1016/j.kint.2017.06.030 · Cited by 448
Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury
Fakhruddin, S., Alanazi, W., & Jackson, K. E. (2017) · Journal of Diabetes Research · doi:10.1155/2017/8379327 · Cited by 292
Nam, S. A., Kim, W.-Y., Kim, J. W., Park, S. H., Kim, H. L., Lee, M.-S., Komatsu, M., Ha, H., Lim, J. H., Park, C. W., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1356-0 · Cited by 92
Szeto, C.-C., & Li, P. K.-T. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.50 · Cited by 80
Metadata
- Authors
- Loeffler, I., & Wolf, G.
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-12
- Volume
- 29
- Issue
- suppl 1
- Pages
- i37-i45
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2097888088
- Cited by
- 275
- References
- 0
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- closed
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