Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial
Open accessAbstract
BACKGROUND: The purpose of this study was to determine among maintenance hemodialysis patients with echocardiographic left ventricular hypertrophy and hypertension whether in comparison with a β-blocker-based antihypertensive therapy, an angiotensin converting enzyme-inhibitor-based antihypertensive therapy causes a greater regression of left ventricular hypertrophy. METHODS: Subjects were randomly assigned to either open-label lisinopril (n = 100) or atenolol (n = 100) each administered three times per week after dialysis. Monthly monitored home blood pressure (BP) was controlled to <140/90 mmHg with medications, dry weight adjustment and sodium restriction. The primary outcome was the change in left ventricular mass index (LVMI) from baseline to 12 months. RESULTS: At baseline, 44-h ambulatory BP was similar in the atenolol (151.5/87.1 mmHg) and lisinopril groups, and improved similarly over time in both groups. However, monthly measured home BP was consistently higher in the lisinopril group despite the need for both a greater number of antihypertensive agents and a greater reduction in dry weight. An independent data safety monitoring board recommended termination because of cardiovascular safety. Serious cardiovascular events in the atenolol group occurred in 16 subjects, who had 20 events, and in the lisinopril group in 28 subjects, who had 43 events {incidence rate ratio (IRR) 2.36 [95% confidence interval (95% CI) 1.36-4.23, P = 0.001]}. Combined serious adverse events of myocardial infarction, stroke and hospitalization for heart failure or cardiovascular death in the atenolol group occurred in 10 subjects, who had 11 events and in the lisinopril group in 17 subjects, who had 23 events (IRR 2.29, P = 0.021). Hospitalizations for heart failure were worse in the lisinopril group (IRR 3.13, P = 0.021). All-cause hospitalizations were higher in the lisinopril group [IRR 1.61 (95% CI 1.18-2.19, P = 0.002)]. LVMI improved with time; no difference between drugs was noted. CONCLUSIONS: Among maintenance dialysis patients with hypertension and left ventricular hypertrophy, atenolol-based antihypertensive therapy may be superior to lisinopril-based therapy in preventing cardiovascular morbidity and all-cause hospitalizations. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases; ClinicalTrials.gov number: NCT00582114).
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During the last two decades, HBPM has been used increasingly in clinical hypertension research.
“During the last two decades, HBPM has been used increasingly in clinical hypertension research [17,155,267–273].”
During the last two decades, HBPM has been used increasingly in clinical hypertension research.
“During the last two decades, HBPM has been used increasingly in clinical hypertension research [17,155,267–273].”
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- Authors
- Agarwal, R., Sinha, A. D., Pappas, M. K., Abraham, T. N., & Tegegne, G. G.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- Corresponding author
- Agarwal, Rajiv
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-06
- Volume
- 29
- Issue
- 3
- Pages
- 672-681
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- PMC
- PMC3938300
- OpenAlex
- W2162199393
- Cited by
- 232
- References
- 22
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 14 · 2023: 19 · 2022: 15 · 2021: 18 · 2020: 21 · 2019: 16 · 2018: 19 · 2017: 19 · 2016: 24 · 2015: 24 · 2014: 17 · 2013: 1
- FWCI
- 19.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Nephrology Dialysis Transplantation (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, other-oa)
- Purdue University Indianapolis (Indiana University) (submittedVersion, other-oa)
- Publisher
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (2R01-DK063020-10)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- hypertension, hemodialysis, lisinopril, atenolol, left ventricular hypertrophy, left ventricular mass index, antihypertensive therapy, ACE inhibitors, beta-blockers, cardiovascular events, heart failure hospitalization, dry weight adjustment, sodium restriction, end-stage renal disease, ambulatory blood pressure monitoring, cardiovascular safety, trial termination
- MeSH terms
- Adult, Aged, Antihypertensive Agents, Atenolol, Double-Blind Method, Female, Renal Dialysis, Humans, Hypertension, Kidney Failure, Chronic, Male, Middle Aged, Myocardial Infarction, Treatment Failure, Hypertrophy, Left Ventricular, Lisinopril, Early Termination of Clinical Trials
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