Cited by 110Cardiovascular and exercise physiologyPhysical Activity and HealthDialysis and Renal Disease Management

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index; none of the 36 sources its claims cite is checked for support yet.

Randomized controlled trial to evaluate the impact of aerobic exercise on visceral fat in overweight chronic kidney disease patients

Open access
Baria, F., Kamimura, M. A., Aoike, D. T., Ammirati, A., Leister Rocha, M., de Mello, M. T., Cuppari, L.·2014·Nephrology Dialysis Transplantation

Abstract

BACKGROUND: The prevalence of obesity has markedly increased in patients with chronic kidney disease (CKD). Studies on the impact of exercise focusing on obese CKD patients are scarce. Therefore, we aimed to investigate the effect of aerobic exercise performed either in an exercise centre or at home on visceral fat in overweight non-dialysed CKD patients. METHODS: Twenty-seven sedentary men (52.1 ± 9.5 years, body mass index 30.4 ± 3.8 kg/m(2), estimated glomerular filtration rate (eGFR) 27.5 ± 11.6 mL/min) were randomly assigned to a centre-based exercise group (n = 10), home-based exercise group (n = 8) or control group (n = 9). The aerobic training was prescribed according to ventilatory threshold and performed three times per week during 12 weeks. Body composition was assessed by dual energy X-ray absorptiometry (DEXA) and the distribution of abdominal fat by computed tomography. RESULTS: In the centre-based group, visceral fat and waist circumference decreased 6.4 ± 6.4 mm (P < 0.01) and 2.0 ± 2.3 cm (P = 0.03) and leg lean mass increased 0.5 ± 0.4 kg (P < 0.01). No significant changes were observed in the home-based group. Visceral fat increased 5.0 ± 4.4 mm in the control group (P = 0.01). In relation to the control, a group-by-time interaction was significant for visceral fat and waist circumference for both exercise groups and for leg lean mass for the centre-based group. Mean blood pressure decreased in both exercise groups (centre-based 13%, P < 0.01 and home-based 10%, P = 0.03) and eGFR increased 3.6 ± 4.6 mL/min (P = 0.03) in the centre-based group. These parameters remained unchanged in the control group. CONCLUSIONS: Centre-based aerobic exercise is an effective approach to reduce visceral fat besides promoting relevant clinical benefits in male overweight CKD patients.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

In a 12-week randomized controlled trial of 27 sedentary overweight non-dialysed CKD men, centre-based aerobic exercise reduced visceral fat and waist circumference and increased leg lean mass, whereas the control group gained visceral fat. Home-based exercise did not significantly change body composition within the group but appeared to prevent the visceral fat increase seen in controls.

Key findings

  • Centre-based exercise decreased visceral fat by 6.4 ± 6.4 mm (P < 0.01) and waist circumference by 2.0 ± 2.3 cm (P = 0.03), and increased leg lean mass by 0.5 ± 0.4 kg (P < 0.01).
  • Mean blood pressure decreased in both exercise groups (centre-based 13%, P < 0.01; home-based 10%, P = 0.03), and eGFR increased by 3.6 ± 4.6 mL/min (P = 0.03) in the centre-based group.
  • The control group had a significant increase in visceral fat of 5.0 ± 4.4 mm (P = 0.01), with no significant change in waist circumference.
  • No significant changes in body composition were observed within the home-based group, but the paper reports that home-based exercise prevented the increase in visceral fat seen in controls; physical capacity improved in both exercise groups.

Methods

  • Prospective, randomized, controlled interventional trial of 12 weeks. Twenty-nine sedentary men with CKD stages 3 and 4 were recruited; 27 completed follow-up. Patients were randomized to aerobic exercise (n = 19) or control (n = 10); those in the exercise group chose centre-based (n = 10) or home-based (n = 9, with 8 completing) exercise.
  • Aerobic training was prescribed according to ventilatory threshold and performed three times per week for 12 weeks, starting at 30 min with a 10-min increment every 4 weeks. Centre-based patients trained on a treadmill under supervision; home-based patients trained near home with a heart rate monitor, three initial supervised sessions, weekly telephone calls, and monthly visits.
  • Body composition was assessed by DEXA and abdominal fat distribution by computed tomography; physical/functional capacity, blood pressure, and laboratory parameters were measured at baseline and 12 weeks. Analysis used three-way ANOVA, two-way ANOVA for between-group comparisons and group-by-time interaction, repeated-measures ANOVA within groups, and χ² tests for proportions.

Limitations

  • Stated in the paper: findings are limited to overweight non-dialysed CKD men and may not be extrapolated to the general CKD population.
  • Evident from the text: the sample was small (27 completers; centre-based n = 10, home-based n = 8, control n = 9), and the centre-based versus home-based exercise mode was chosen by participants rather than randomized.
  • Evident from the text: the intervention lasted only 12 weeks, and the authors note that more studies are needed to prove definite effectiveness of supervised home-based exercise.

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Integrity signals

Registry

Crossref · 10.1093/ndt/gft529

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Verification

Claims the paper makes

0 of 36 cited sources checked · 0 supported · 0 flagged

Show all 35 claims

  • It may state two separate claims as one. 11
  • The quote only partly states this claim. 2
  • Probably not a substantial claim. 12
21 of 21
  • The paper relies on this without support.

    The present study is the first to show the impact of aerobic exercise as a single intervention on visceral fat reduction in obese CKD patients.

    “To the best of our knowledge, the present study is the first to show the impact of aerobic exercise as a single intervention on visceral fat reduction in obese CKD patients.”
  • The paper relies on this without support.

    Clinical studies of aerobic exercise on kidney function in CKD patients are scarce.

    “clinical studies with CKD patients are scarce”
  • The paper relies on this without support.

    In-centre closely supervised exercise may not be an option for most patients.

    “Considering that in-centre closely supervised exercise may not be an option for most patients”
3 of 3

Claims other papers make about this one

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Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Exercise mode was chosen, not randomly assigned

    Major

    The abstract says patients were randomly assigned to three groups, but the methods say randomization was between exercise and control, after which exercise patients chose the centre-based or home-based mode.

  • Urinary sodium changed despite being described as unchanged

    Minor

    The results say the other laboratory parameters remained unchanged in the centre-based and control groups, but Table 1 reports a significant increase in urinary sodium in the centre-based group.

2 of 2

Citations

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Research works printed but not linked: 1

  1. 2000, American journal of kidney diseases : the official journal of the National Kidney Foundation, 35, S1

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Metadata

Authors
Baria, F., Kamimura, M. A., Aoike, D. T., Ammirati, A., Leister Rocha, M., de Mello, M. T., & Cuppari, L.
Affiliations
Universidade Federal de São Paulo (BR)
Corresponding author
Cuppari, L.
Venue
Nephrology Dialysis Transplantation
Published
2014-01-20
Volume
29
Issue
4
Pages
857-864
ISSN
  • 0931-0509 (ISSN-L)
  • 1460-2385
OpenAlex
W2163076045
Cited by
110
References
48
Citations by year
2026: 5 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 14 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5
FWCI
15.70
Type
journal article
Language
en
Open access
Locations
  • Nephrology Dialysis Transplantation (publishedVersion)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo (09/14786-0)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
aerobic exercise, visceral fat, chronic kidney disease, overweight, obesity, home-based exercise, waist circumference, leg lean mass, blood pressure, estimated glomerular filtration rate, ventilatory threshold, sedentary men
MeSH terms
Adolescent, Adult, Aged, Body Composition, Exercise Therapy, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Exercise, Absorptiometry, Photon, Body Mass Index, Treatment Outcome, Intra-Abdominal Fat, Overweight, Renal Insufficiency, Chronic, Young Adult, Sedentary Behavior

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