The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Primary and secondary glioblastomas: From concept to clinical diagnosis
Open accessAbstract
Glioblastomas may develop de novo (primary glioblastomas) or through progression from low-grade or anaplastic astrocytomas, (secondary glioblastomas). These subtypes of glioblastoma constitute distinct disease entities that evolve through different genetic pathways, affect patients at different ages, and are likely to differ in prognosis and response to therapy. Primary glioblastomas develop in older patients and typically show EGFR overexpression, PTEN (MMAC1) mutations, CDKN2A (p16) deletions, and less frequently, MDM2 amplification. Secondary glioblastomas develop in younger patients and often contain TP53 mutations as the earliest detectable alteration. These characteristics are derived largely from patients selected on the basis of clinical history and sequential biopsies. Currently available data are insufficient for a substitution of histologic classification and grading of astrocytic tumors by genetic typing alone. More subtypes of glioblastomas may exist with intermediate clinical and genetic profiles, a factor exemplified by the giant-cell glioblastoma that clinically and genetically occupies a hybrid position between primary (de novo) and secondary glioblastomas. Future research should aim at the identification of criteria for a combined clinical, histologic, and genetic classification of astrocytic tumors.
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Cited by
Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.020 · Cited by 7,575
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
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Self-citationCost of Migration: Invasion of Malignant Gliomas and Implications for Treatment
Giese, A., Bjerkvig, R., Berens, M. E., & Westphal, M. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.063 · Cited by 1,200
Beier, D., Hau, P., Proescholdt, M., Lohmeier, A., Wischhusen, J., Oefner, P. J., Aigner, L., Brawanski, A., Bogdahn, U., & Beier, C. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4180 · Cited by 1,153
Metadata
- Authors
- Kleihues, P., & Ohgaki, H.
- Venue
- Neuro-Oncology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 1
- Issue
- 1
- Pages
- 44-51
- ISSN
- 1522-8517 (ISSN-L)
- 1523-5866
- OpenAlex
- W2114292508
- Cited by
- 586
- References
- 84
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
