The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges
Open accessAbstract
In patients with certain hematologic malignancies, the use of autologous T cells genetically modified to express chimeric antigen receptors (CARs) has led to unprecedented clinical responses. Although progress in solid tumors has been elusive, recent clinical studies have demonstrated the feasibility and safety of CAR T-cell therapy for glioblastoma. In addition, despite formidable barriers to T-cell localization and effector function in glioblastoma, signs of efficacy have been observed in select patients. In this review, we begin with a discussion of established obstacles to systemic therapy in glioblastoma and how these may be overcome by CAR T cells. We continue with a summary of previously published CAR T-cell trials in GBM, and end by outlining the key therapeutic challenges associated with the use of CAR T cells in this disease.
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Self-citationBevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
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Metadata
- Authors
- Bagley, S. J., Desai, A. S., Linette, G. P., June, C. H., & O’Rourke, D. M.
- Venue
- Neuro-Oncology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-03-02
- Volume
- 20
- Issue
- 11
- Pages
- 1429-1438
- ISSN
- 1522-8517 (ISSN-L)
- 1523-5866
- OpenAlex
- W2790865199
- Cited by
- 312
- References
- 92
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bagley, S. J., Desai, A. S., Linette, G. P., June, C. H., & O’Rourke, D. M. (2018). CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges. Neuro-Oncology. https://doi.org/10.1093/neuonc/noy032
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
