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Cited by 40Smoking Behavior and CessationHealth Promotion and Cardiovascular PreventionCardiac Health and Mental Health

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Smoking Cessation, Weight Gain, Cardiovascular Risk, and All-Cause Mortality: A Meta-analysis

Wang, Xiaowen, Qin, Li-Qiang, Arafa, Ahmed, Eshak, Ehab S, Hu, Yonghua, Dong, Jia-Yi·2021·Nicotine & Tobacco Research
DOI 10.1093/ntr/ntab076
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Abstract

Introduction: Quitting smoking usually results in weight gain, rising the concern that weight gain after smoking cessation may attenuate the benefits of smoking quitting on cardiovascular health. Aims and Methods: We aimed to examine the risk of cardiovascular disease (CVD) among smoking quitters compared with smokers, stratified by post-cessation weight change. We searched PubMed, Scopus, and Web of Science for eligible studies published before September 2020. Cohort studies examining the relative risk of CVD among smoking quitters stratified by post-cessation weight change, with smokers being treated as the reference, were included. Two investigators extracted the key characteristics of each included study using a standard electronic form. Results: We identified nine studies for this meta-analysis. Compared with smokers, the pooled RRs (95% confidence interval) of CVD among quitters with weight gain and among those without were 0.74 [0.66, 0.83] and 0.86 [0.80, 0.92], with no evidence of heterogeneity between studies being observed. Moreover, the associations appeared to be significantly stronger among quitters with weight gain than those without, particularly in the analysis of coronary heart disease (CHD) and stroke (pooled RRs = 0.65 [0.59, 0.71] vs. 0.79 [0.71, 0.88] for CHD and 0.67 [0.62, 0.73] vs. 0.76 [0.72, 0.81] for stroke, respectively; p for interaction <.05). Conclusions: Smoking cessation was associated with a significantly lower risk of CVD and all-cause mortality, regardless of post-cessation weight gain. A greater risk reduction among quitters with weight gain than those without merits further investigations. Implications: Quitting smoking usually results in weight gain and increases the risk of type 2 diabetes. We found that the risk reduction in CVD and all-cause mortality associated with smoking cessation was greater in quitters with weight gain than that in quitters without, especially in CHD and stroke. Despite weight gain and increased risk of type 2 diabetes, quitting smoking remains effective in the prevention of CVD.

Overview

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Registry

Crossref · 10.1093/ntr/ntab076

Cites

37 of 37 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 37 references

Research works printed but not linked: 2

  1. Substance A, Mental Health Services A, Office of the Surgeon G. Publications and Reports of the Surgeon General, 2020, Smoking Cessation: A Report of the Surgeon General
  2. AskMayoExpert, 2016, Abnormal Weight Loss

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Metadata

Authors
Wang, X., Qin, L.-Q., Arafa, A., Eshak, E. S., Hu, Y., & Dong, J.-Y.
Affiliations
  • Peking University (CN)
  • Soochow University (CN)
  • Beni-Suef University (EG)
  • Minia University (EG)
  • The University of Osaka (JP)
Corresponding author
Dong, Jia-Yi
ORCID
Venue
Nicotine & Tobacco Research
Publisher
Oxford University Press (OUP)
Published
2021-04-20
Volume
23
Issue
12
Pages
1987-1994
ISSN
  • 1462-2203 (ISSN-L)
  • 1469-994X
DOI
10.1093/ntr/ntab076
OpenAlex
W3156420336
Cited by
40
References
37
Citations by year
2026: 11 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 6
FWCI
0.81
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Nicotine & Tobacco Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
smoking cessation, post-cessation weight gain, cardiovascular risk, all-cause mortality, coronary artery disease, stroke, type 2 diabetes, weight gain after quitting
MeSH terms
Heart Disease Risk Factors, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Risk Factors, Weight Gain, Smoking Cessation

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CoChat. (2026). Citation check: Smoking Cessation, Weight Gain, Cardiovascular Risk, and All-Cause Mortality: A Meta-analysis. https://app.cochat.ai/papers/10.1093/ntr/ntab076
The paper
Wang, X., Qin, L.-Q., Arafa, A., Eshak, E. S., Hu, Y., & Dong, J.-Y. (2021). Smoking Cessation, Weight Gain, Cardiovascular Risk, and All-Cause Mortality: A Meta-analysis. Nicotine & Tobacco Research. https://doi.org/10.1093/ntr/ntab076

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.