Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review
Abstract
Context The anti-inflammatory activity of long-chain n-3 polyunsaturated fatty acids (PUFAs) has been established in several chronic inflammatory diseases but has yet to be demonstrated in inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD). Objective The aim of this systematic review was to investigate, using PRISMA guidelines, the relationship between the intake of long-chain n-3 PUFAs and the prevalence, severity, and health outcomes of COPD. Data sources Eight health databases and the World Health Organization's international clinical trial registry were searched for relevant studies. Study selection Experimental or observational studies that were published in English and that assessed long-chain n-3 PUFA intake (by determining habitual consumption and/or tissue levels) in adults with COPD were included. Data extraction Publication demographics, participant characteristics, type of intervention or exposure, long-chain n-3 PUFA intake, pulmonary function, COPD mortality, and COPD severity were independently extracted from each article by 2 authors using a prospectively designed data extraction tool. Data synthesis All 11 of the studies included in the review were observational. Approximately equal numbers of studies reported significant (n = 6, 5 inverse) relationships or no significant relationships (n = 5) between either consumption of long-chain n-3 PUFAs or levels of long-chain n-3 PUFAS in tissue and a COPD outcome. Conclusions Current evid…
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As of the time of publication there were only four observational studies investigating the relationship between omega-3 polyunsaturated fatty acids and inflammation in people with COPD.
“as of the time of publication there were only four observational studies investigating the relationship between omega-3 polyunsaturated fatty acids and inflammation in people with COPD (Fulton et al. 2015b)”
From Continued post-retraction citation of a fraudulent clinical trial report, 11 years after it was retracted for falsifying data (2020) · cites this paper as Fulton et al. 2015b
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1 retracted
RETRACTED: Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Markers in COPD
Matsuyama, W., Mitsuyama, H., Watanabe, M., Oonakahara, K.-I., Higashimoto, I., Osame, M., & Arimura, K. (2005) · Chest · doi:10.1378/chest.128.6.3817 · Cited by 108 · see citing works
RetractedOmega-3 fatty acids and incident type 2 diabetes: A systematic review and meta-analysis
Wu, J. H. Y., Micha, R., Imamura, F., Pan, A., Biggs, M. L., Ajaz, O., Djousse, L., B. Hu, F., & Mozaffarian, D. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001602 · Cited by 340 · see citing works
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Schneider, J., Ye, D., Hill, A. M., & Whitehorn, A. S. (2020) · Scientometrics · doi:10.1007/s11192-020-03631-1 · Cited by 88 · see citing works
Self-citation
- Authors
- Fulton, A. S., Hill, A. M., Williams, M. T., Howe, P. R. C., & Coates, A. M.
- Affiliations
- University of South Australia (AU)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-07-15
- Volume
- 73
- Issue
- 9
- Pages
- 612-623
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2253492990
- Cited by
- 26
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 3
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Queensland ePrints (University of Southern Queensland) (submittedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- n-3 long-chain polyunsaturated fatty acids, omega-3 fatty acids, chronic obstructive pulmonary disease, dietary intake, lung function, COPD severity, COPD mortality, anti-inflammatory activity, lung inflammation
- MeSH terms
- Chronic Disease, Fatty Acids, Unsaturated, Humans, Fatty Acids, Omega-3, Prevalence, Pulmonary Disease, Chronic Obstructive
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