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Esophageal Cancer
Abstract
Cancer of the esophagus is the eighth most common malignancy worldwide in terms of incident cases and the sixth most common for cancer deaths. The two main histopathologic subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EADC), have strikingly different clinical and epidemiologic features. ESCC occurs throughout the esophagus and is the most common histologic subtype globally; over 90% of cases in the traditionally high-risk regions of Eastern Asia and Eastern and Southern Africa are ESCC. The incidence of ESCC is decreasing worldwide. In some high-risk areas in Asia the decrease was preceded by economic development and improvements in diet, whereas in high-income countries the decrease followed reductions in cigarette smoking. In contrast, the incidence of EADC continues to increase in many high- and middle-income countries, especially among white men. EADC develops in the lower third of the esophagus, primarily because of gastroesophageal reflux disease (GERD) and obesity.
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Adenocarcinoma represents around two thirds of esophageal cancer cases in higher HDI settings and is associated with excess body weight, gastroesophageal reflux disease, and Barrett esophagus.
“Adenocarcinoma represents around two thirds of cases in higher HDI settings and is associated with excess body weight, gastroesophageal reflux disease, and Barrett esophagus.176”
From Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (2024) · cites this paper as [176]
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Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024) · CA: a cancer journal for clinicians · doi:10.3322/caac.21834 · Cited by 27,064
Interventional gastroenterology in oncology
Wadhwa, V., Patel, N., Grover, D., Ali, F. S., & Thosani, N. C. (2022) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21766 · Cited by 63
Boldrin, E., Mazza, M., Piano, M. A., Alfieri, R., Montagner, I. M., Magni, G., Scaini, M. C., Vassallo, L., Rosato, A., Pilati, P., et al. (2022) · Cancers · doi:10.3390/cancers14092180 · Cited by 13
HER2-Positive Gastroesophageal Cancers Are Associated with a Higher Risk of Brain Metastasis
Tincknell, G., Naveed, A., Nankervis, J., Mukhtiar, A., Piper, A., Becker, T. M., Chantrill, L. A., Aghmesheh, M., Vine, K. L., Ranson, M., et al. (2022) · Cancers · doi:10.3390/cancers14235754 · Cited by 10
Li, Z., Gai, C., Zhang, Y., et al. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002342 · Cited by 6
Gun, R. T., & Kendall, G. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-44847-4 · Cited by 3
Pathological Characteristics and Prognosis of Esophageal Cancer Based on SEER Database
张, 云. (2020) · Advances in Clinical Medicine · doi:10.12677/acm.2020.107226
Metadata
- Authors
- Blot, W. J., & Tarone, R. E.
- Venue
- Oxford Scholarship Online
- Publisher
- Oxford University Press
- Published
- 2017-12-21
- OpenAlex
- W4231784567
- Cited by
- 7
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2020: 1
- FWCI
- 0.72
- Type
- book
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Surgery › Esophageal and GI Pathology
- Keywords
- esophageal cancer, esophageal squamous cell carcinoma, esophageal adenocarcinoma, incidence trends, cigarette smoking, gastroesophageal reflux disease, obesity, diet and cancer risk, histological subtypes
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