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Cited by 12Cancer Risks and FactorsGlobal Cancer Incidence and ScreeningBreast Cancer Treatment Studies

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Breast Cancer

Brinton, Louise A., Gaudet, Mia M., Gierach, Gretchen L.·2017·Oxford Scholarship Online
DOI 10.1093/oso/9780190238667.003.0045
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Abstract

Breast cancer is the most frequently diagnosed cancer in women worldwide, with annual estimates of 1.7 million newly diagnosed cases and 522,000 deaths. Although more breast cancers are diagnosed in economically developed than in developing countries, the reverse is true for mortality, reflecting limited screening and less effective treatments in the latter. Breast cancer incidence has been on the rise in the United States for many years, but in recent years this is restricted to certain subgroups, while internationally there have been continued generalized increases, likely reflecting adoption of more Westernized lifestyles. Breast cancer is widely recognized as being hormonally influenced, with most of the established risk factors believed to reflect the influence of cumulative exposure of the breast to stimulatory effects of ovarian hormones—leading to increased cellular proliferation, which in turn can result in genetic errors during cell division.

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Crossref · 10.1093/oso/9780190238667.003.0045

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  • The higher breast cancer incidence rates in transitioned versus transitioning countries reflect a higher prevalence of numerous reproductive and lifestyle risk factors, including early age at menarche, later age at menopause, advanced age at first birth, fewer number of children, less breastfeeding, hormone-replacement therapy, oral contraceptive, alcohol intake, excess body weight, and physical.

    “The higher incidence rates in transitioned versus transitioning countries reflect a higher prevalence of numerous reproductive and lifestyle risk factors, including early age at menarche, later age at menopause, advanced age at first birth, fewer number of children, less breastfeeding, hormone-replacement therapy, oral contraceptive, alcohol intake, excess body weight, and physical inactivity.45”

    From Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (2024) · cites this paper as [45]

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Metadata

Authors
Brinton, L. A., Gaudet, M. M., & Gierach, G. L.
ORCID
Venue
Oxford Scholarship Online
Publisher
Oxford University Press
Published
2017-12-21
DOI
10.1093/oso/9780190238667.003.0045
OpenAlex
W4238620009
Cited by
12
References
0
Citations by year
2026: 2 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 1
FWCI
0.00
Type
book
Language
en
Open access
closed
Locations
Oxford University Press eBooks (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
breast cancer, incidence, mortality, screening, risk factors, endocrine effects, ovarian hormones, Western lifestyle, developing countries

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