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Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study
Abstract
Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988-1990) to collect dietary information for that time period and a period of time 10 years earlier (1978-1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 microns) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to late-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM.
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“Results from observational studies that assessed the effect of dietary antioxidants on risk for age-related macular degeneration have been inconsistent.90–95”
From Age-related macular degeneration (2008) · cites this paper as [93]
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ResultA Clinician's View of the Molecular Genetics of Age-Related Maculopathy
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“While no study has evaluated subjects with low MPOD prior to the onset of ARMD, the Blue Mountain Study, Beaver Dam Study and Aged-Related Eye Disease Study have shown that a higher dietary intake of lutein and zeaxanthin is associated with a reduced risk of developing advanced ARMD [39-41].”
BackgroundEpidemiology of Age-Related Macular Degeneration Early in the 21st Century
Wang, J. J., Mitchell, P., & Klein, R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-186-4_2 · Cited by 1
Self-citationRubin, G., & Cruickshanks, K. (2000) · Elsevier eBooks · doi:10.1016/b978-012288145-9/50111-x
Die altersabhängige Makuladegeneration — eine Übersicht
Steinberg, J., Uibel, S., Berndt, T., Müller, D., Quarcoo, D., & Groneberg, D. A. (2011) · Zentralblatt für Arbeitsmedizin Arbeitsschutz und Ergonomie · doi:10.1007/bf03345002 · Cited by 1
Age-Related Macular Degeneration and Vision Impairment
Wright, C. B., & Ambati, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_16 · Cited by 1
Nutritional supplement for age-related macular degeneration
Ma, D. J., & Yu, H. (2016) · Journal of Korean Medical Association · doi:10.5124/jkma.2016.59.12.955 · Cited by 3
“하지만 비버댐 안 연구(Beaver Dam Eye Study) [14]와 블루마운틴 안연구 (Blue Mountains Eye Study) [12]를 비롯하여 여러 임상 시험에서는 비타민C 섭취나 보충제 사용과 AMD 위험성 사 이에는 명확한 연관성이 발견되지 않았다.”
Metadata
- Authors
- VandenLangenberg, G. M., Mares-Perlman, J. A., Klein, R., Klein, B. E. K., Brady, W. E., & Palta, M.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Mares-Perlman, J. A.
- ORCID
- Palta, M.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07-15
- Volume
- 148
- Issue
- 2
- Pages
- 204-214
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2036317458
- Cited by
- 234
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 13
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (EY O6594, EYO8012)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related maculopathy, antioxidants, dietary zinc, vitamin E, carotenoids, drusen, pigmentary abnormalities, macular degeneration, dietary intake, Beaver Dam Eye Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Antioxidants, Diet, Female, Humans, Macular Degeneration, Male, Middle Aged, Pigment Epithelium of Eye, Prospective Studies, Wisconsin, Zinc, Confounding Factors, Epidemiologic, Incidence, Logistic Models
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