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Cited by 470Cervical Cancer and HPV ResearchWomen's cancer prevention and managementReproductive tract infections research

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Mathematical Model for the Natural History of Human Papillomavirus Infection and Cervical Carcinogenesis

Myers, E. R., McCrory, D. C., Nanda, K., Bastian, L., Matchar, D. B.·2000·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a010166
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Abstract

The authors constructed a Markov model as part of a systematic review of cervical cytology conducted at the Duke University Evidence-based Practice Center (Durham, North Carolina) between October 1997 and September 1998. The model incorporated states for human papillomavirus infection (HPV), low- and high-grade squamous intraepithelial lesions, and cervical cancer stages I-IV to simulate the natural history of HPV infection in a cohort of women from ages 15 to 85 years. The age-specific incidence rate of HPV, and regression and progression rates of HPV and squamous intraepithelial lesions, were obtained from the literature. The effects of varying natural history parameters on cervical cancer incidence were evaluated by using sensitivity analysis. The base-case model resulted in a lifetime cervical cancer risk of 3.67% and a lifetime cervical cancer mortality risk of 1.26%, with a peak incidence of 81/100,000 at age 50 years. Age-specific distributions of precursors were similar to reported data. Lifetime risk of cancer was most sensitive to the incidence of HPV and the probability of rapid HPV progression to high-grade lesions (two- to threefold variations in risk). The model approximates the age-specific incidence of cervical cancer and provides a tool for evaluating the natural history of HPV infection and cervical cancer carcinogenesis as well as the effectiveness and cost-effectiveness of primary and secondary prevention strategies.

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Crossref · 10.1093/oxfordjournals.aje.a010166

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Metadata

Authors
Myers, E. R., McCrory, D. C., Nanda, K., Bastian, L., & Matchar, D. B.
Affiliations
Duke University (US)
Corresponding author
Myers, E. R.
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2000-06-15
Volume
151
Issue
12
Pages
1158-1171
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a010166
OpenAlex
W2113839478
Cited by
470
References
49
Citations by year
2026: 4 · 2025: 16 · 2024: 8 · 2023: 14 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 19 · 2017: 20 · 2016: 12 · 2015: 22 · 2014: 24 · 2013: 32 · 2012: 19
FWCI
8.82
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (290-97-0014)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
HPV infection, cervical carcinogenesis, natural history of HPV infection, squamous intraepithelial lesions, cervical cancer incidence, cervical cancer mortality, lifetime cancer risk, Markov model, cervical cancer prevention, sensitivity analysis
MeSH terms
Adolescent, Adult, Aged, Antiviral Agents, Cell Transformation, Neoplastic, Uterine Cervical Neoplasms, Cost-Benefit Analysis, Female, Humans, Markov Chains, Middle Aged, Models, Theoretical, Tumor Virus Infections, Incidence, Risk Assessment, Papillomaviridae, Papillomavirus Infections

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