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Cited by 144Hepatitis B Virus StudiesHepatocellular Carcinoma Treatment and PrognosisHepatitis C virus research

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Prospective Study of Hepatitis B and C Viral Infections, Cigarette Smoking, Alcohol Consumption, and Other Factors Associated with Hepatocellular Carcinoma Risk in Japan

Mori, M., Hara, M., Wada, I., Hara, T., Yamamoto, K., Honda, M., Naramoto, J.·2000·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a010180
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Abstract

This community-based prospective study examined the effects of viral infections and lifestyle habits on hepatocellular carcinoma (HCC) risk in Japan. A baseline survey was conducted for 981 males and 2,078 females in June 1992 and evaluated hepatitis B surface antigen, second-generation hepatitis C virus antibody, and history of cigarette smoking and habitual alcohol consumption. By March 1997, 14 males and 8 females had been newly diagnosed with HCC. After controlling for gender and age by using the Cox model, the authors found that positivity for hepatitis B surface antigen (hazard ratio = 7.28, 95% confidence interval: 1.62, 32.61; p < 0.01) and positivity for high-titer hepatitis C virus antibody (hazard ratio = 40.38, 95% confidence interval: 11.71, 139.21; p < 0.001) were significantly associated with HCC risk, although a history of smoking or alcohol consumption was not significantly related to risk. There was a significant interaction on an additive scale for the risk of HCC development between high-titer hepatitis C virus antibody status and a history of smoking (p < 0.05) in spite of no significant interaction on a multiplicative scale. Although preventing the transmission of hepatitis viruses is most important for reducing the risk of HCC, intervention regarding lifestyle habits such as cigarette smoking should not go unheeded.

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Crossref · 10.1093/oxfordjournals.aje.a010180

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40 of 40 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Mori, M., Hara, M., Wada, I., Hara, T., Yamamoto, K., Honda, M., & Naramoto, J.
Affiliations
Saga University (JP)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2000-01-15
Volume
151
Issue
2
Pages
131-139
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a010180
OpenAlex
W2124073571
Cited by
144
References
40
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 7 · 2012: 10
FWCI
7.22
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Keywords
hepatocellular carcinoma, hepatitis B, hepatitis C, hepatitis B surface antigen, anti-HCV antibodies, cigarette smoking, alcohol consumption, lifestyle risk factors, cancer risk
MeSH terms
Adult, Aged, Alcohol Drinking, Female, Hepatitis B, Hepatitis B Surface Antigens, Hepatitis C, Carcinoma, Hepatocellular, Humans, Japan, Life Style, Liver Neoplasms, Male, Middle Aged, Prospective Studies, Risk Factors, Smoking, Cohort Studies, Proportional Hazards Models, Hepatitis C Antibodies

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