The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Prospective Study of Hepatitis B and C Viral Infections, Cigarette Smoking, Alcohol Consumption, and Other Factors Associated with Hepatocellular Carcinoma Risk in Japan
Abstract
This community-based prospective study examined the effects of viral infections and lifestyle habits on hepatocellular carcinoma (HCC) risk in Japan. A baseline survey was conducted for 981 males and 2,078 females in June 1992 and evaluated hepatitis B surface antigen, second-generation hepatitis C virus antibody, and history of cigarette smoking and habitual alcohol consumption. By March 1997, 14 males and 8 females had been newly diagnosed with HCC. After controlling for gender and age by using the Cox model, the authors found that positivity for hepatitis B surface antigen (hazard ratio = 7.28, 95% confidence interval: 1.62, 32.61; p < 0.01) and positivity for high-titer hepatitis C virus antibody (hazard ratio = 40.38, 95% confidence interval: 11.71, 139.21; p < 0.001) were significantly associated with HCC risk, although a history of smoking or alcohol consumption was not significantly related to risk. There was a significant interaction on an additive scale for the risk of HCC development between high-titer hepatitis C virus antibody status and a history of smoking (p < 0.05) in spite of no significant interaction on a multiplicative scale. Although preventing the transmission of hepatitis viruses is most important for reducing the risk of HCC, intervention regarding lifestyle habits such as cigarette smoking should not go unheeded.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We used the resulting predicted exposure fractions among prevalent cases as a proxy for PAFs for liver cirrhosis. This follows from the direct method of approximating PAFs:”
From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [35]
Citations
Cites
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Cancer Incidence in Five Continents
Doll, R., Muir, C. S., & Waterhouse, J. A. H. (1970) · Springer eBooks · doi:10.1007/978-3-642-85851-2 · Cited by 8,485
Epidemiologic Research: Principles and Quantitative Methods.
Mayer, L. S., Kleinbaum, D. G., Kupper, L. L., & Morgenstern, H. (1984) · Journal of the American Statistical Association · doi:10.2307/2288427 · Cited by 2,905
HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS
Beasley, R. P., Lin, C., Hwang, L., & Chien, C. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90585-7 · Cited by 2,856
Hennekens, C. H., Buring, J. E., & Mayrent, S. L. (1987) · Medical Entomology and Zoology · Cited by 2,319
Statistical Methods in Epidemiology
(2012) · Springer eBooks · doi:10.1007/springerreference_205629 · Cited by 1,123
Hepatitis C Virus Infection as a Risk Factor for Hepatocellular Carcinoma in Patients with Cirrhosis
Simonetti, R. G., Cammà, C., Fiorello, F., Cottone, M., Rapicetta, M., Marino, L., Fiorentino, G., Craxı̀, A., Ciccaglione, A. R., Giuseppetti, R., et al. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-2-97 · Cited by 352
Yu, M., Hsu, F.-C., Sheen, I. S., Chu, C., Lin, D., Chen, C., & Liaw, Y. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009060 · Cited by 289
Chen, C., Liang, K., Chang, A.-S., Chang, Y.-C., Lu, S., Liaw, Y., Chang, W., Sheen, M., & Lin, T.-M. (1991) · Hepatology · doi:10.1002/hep.1840130303 · Cited by 245
Donato, F., TAGGER, A., Chiesa, R., Ribero, M. L., Tomasoni, V., Fasola, M., Gelatti, U., Portera, G., Boffetta, P., & Nardi, G. (1997) · Hepatology · doi:10.1002/hep.510260308 · Cited by 232
Cited by
Sorted by citations
Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference
Bruix, J., Sherman, M., Llovet, J. M., Beaugrand, M., Lencioni, R. A., Burroughs, A. K., Christensen, E., Pagliaro, L., Colombo, M., & Rodés, J. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00130-1 · Cited by 4,063
Natural history of chronic hepatitis C
Seeff, L. B. (2002) · Hepatology · doi:10.1053/jhep.2002.36806 · Cited by 1,550
Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis
Mokdad, A. A., Lopez, A. D., Shahraz, S., Lozano, R., Mokdad, A. H., Stanaway, J., Murray, C. J., & Naghavi, M. (2014) · BMC Medicine · doi:10.1186/s12916-014-0145-y · Cited by 1,129
Alcohol and hepatocellular carcinoma
Morgan, T. R. M., Mandayam, S., & Jamal, M. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.020 · Cited by 631
Hepatocellular carcinoma epidemiology
Bosetti, C., Turati, F., & Vecchia, C. L. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.08.007 · Cited by 543
Metadata
- Authors
- Mori, M., Hara, M., Wada, I., Hara, T., Yamamoto, K., Honda, M., & Naramoto, J.
- Affiliations
- Saga University (JP)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-15
- Volume
- 151
- Issue
- 2
- Pages
- 131-139
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2124073571
- Cited by
- 144
- References
- 40
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 7 · 2012: 10
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Keywords
- hepatocellular carcinoma, hepatitis B, hepatitis C, hepatitis B surface antigen, anti-HCV antibodies, cigarette smoking, alcohol consumption, lifestyle risk factors, cancer risk
- MeSH terms
- Adult, Aged, Alcohol Drinking, Female, Hepatitis B, Hepatitis B Surface Antigens, Hepatitis C, Carcinoma, Hepatocellular, Humans, Japan, Life Style, Liver Neoplasms, Male, Middle Aged, Prospective Studies, Risk Factors, Smoking, Cohort Studies, Proportional Hazards Models, Hepatitis C Antibodies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
