The DOI matches its Crossref record.
VIRAL EXPOSURE AND AUTISM
Abstract
The hypothesis that direct exposure to or clinical illness with measles, rubella, mumps or chickenpox may play a causal role in autism has been evaluated. The study subjects were 163 cases of autism and their 355 unaffected siblings. Medical data relating to prenatal life and early infancy were obtained by interviewing the parents, and from medical records. Medical records were found for only about half the instances In which a pertinent illness or exposure was reported in the home Interview. However, there was no evidence of systematic bias In recall on the part of parents when reporting on an index case. When medical records and parental statements were both available they were relatively consonant. Increased frequency of combined illness and exposure was seen for the cases relative to their sibling controls with regard to prenatal measles, rubella and mumps and to postnatal mumps. Yet the proportion of cases with histories of viral experience during the periods of interest was small, indicating that these four viruses were unlikely to have played a major role In any substantial proportion of the cases. Some associations were noted with parental histories of other infections during gestation or infancy. Again, however, the proportion of cases that could be accounted for by any of these associations, even if causal, is small.
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“Varying reports have also implicated measles and mumps (Deykin and MacMahon, 1979), cytomegalovirus (Libbey et al, 2005), polyomaviruses (Lintas et al, 2010), and influenza”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Deykin and MacMahon, 1979
In the citing paper
“thus establishing a link between CRS and autism that has been supported by others”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Deykin and MacMahon, 1979
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Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders
Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1006-y · Cited by 916
Bailey, A. J., Phillips, W., & Rutter, M. L. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01381.x · Cited by 765
Prenatal risk factors for autism: comprehensive meta-analysis
Gardener, H., Spiegelman, D., & Buka, S. L. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.051672 · Cited by 736
Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi123 · Cited by 727
Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-analysis
Gardener, H., Spiegelman, D., & Buka, S. L. (2011) · Pediatrics · doi:10.1542/peds.2010-1036 · Cited by 665
Metadata
- Authors
- DEYKIN, E. Y., & MACMAHON, B.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-06
- Volume
- 109
- Issue
- 6
- Pages
- 628-638
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W1943382614
- Cited by
- 161
- References
- 0
- Citations by year
- 2024: 4 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 10 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, viral exposure, measles, rubella, mumps, varicella, prenatal infection, postnatal infection, siblings, medical records, autism etiology
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Chickenpox, Child, Child, Preschool, Ear Diseases, Female, Fever of Unknown Origin, Herpesviridae Infections, Humans, Infant, Infections, Influenza, Human, Male, Massachusetts, Measles, Mumps, Nervous System Diseases, Pneumonia, Pregnancy, Pregnancy Complications, Infectious, Rubella, Virus Diseases
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