The DOI matches its Crossref record.
FREQUENCY OF ILLNESS ASSOCIATED WITH EPIDEMIC HEPATITIS A VIRUS INFECTIONS IN ADULTS
Abstract
Hepatitis A virus infection is often described as mild or asymptomatic, particularly in children. The failure of most adults who are found to be immune to remember symptoms of an illness suggestive of hepatitis A virus supports this belief. In 1982, two large outbreaks occurred in well documented populations of military personnel. These outbreaks were each extensively studied epidemiologically and serologically. It was found that 28/29 (96.6%) hepatitis A infections recognized prior to immune serum globulin in Outbreak A and 35/46 (76.1%) infections in Outbreak A were symptomatic. Symptomatic cases failed to occur beyond eight days of immune serum globulin administration to these predominantly susceptible groups. Between 40 and 70% of patients were icteric. Apparent contrasts in symptoms associated with hepatitis A infection in adults and children suggest a basic age-dependent difference in immune response to such infection.
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Citations
Cited by
Cuthbert, J. A. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.1.38-58.2001 · Cited by 469
Modeling the Risk From Giardia and Viruses in Drinking Water
Regli, S., Rose, J. B., Haas, C. N., & Gerba, C. P. (1991) · Journal AWWA · doi:10.1002/j.1551-8833.1991.tb07252.x · Cited by 395
Sensitive populations: who is at the greatest risk?
Gerba, C. P., Rose, J. B., & Haas, C. N. (1996) · International Journal of Food Microbiology · doi:10.1016/0168-1605(96)00996-8 · Cited by 384
Type A Viral Hepatitis: New Developments in an Old Disease
Lemon, S. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510243131706 · Cited by 338
Self-citationLemon, S. M., Ott, J. J., Van Damme, P., & Shouval, D. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.08.034 · Cited by 336
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Metadata
- Authors
- LEDNAR, W. M., LEMON, S. M., KIRKPATRICK, J. W., REDFIELD, R. R., FIELDS, M. L., & KELLEY, P. W.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-08
- Volume
- 122
- Issue
- 2
- Pages
- 226-233
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W1952904289
- Cited by
- 343
- References
- 0
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: FREQUENCY OF ILLNESS ASSOCIATED WITH EPIDEMIC HEPATITIS A VIRUS INFECTIONS IN ADULTS. https://app.cochat.ai/papers/10.1093/oxfordjournals.aje.a114093
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- LEDNAR, W. M., LEMON, S. M., KIRKPATRICK, J. W., REDFIELD, R. R., FIELDS, M. L., & KELLEY, P. W. (1985). FREQUENCY OF ILLNESS ASSOCIATED WITH EPIDEMIC HEPATITIS A VIRUS INFECTIONS IN ADULTS. American Journal of Epidemiology. https://doi.org/10.1093/oxfordjournals.aje.a114093
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
