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Cited by 217Hormonal and reproductive studiesSperm and Testicular FunctionDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record.

ENDOGENOUS SEX HORMONE LEVELS IN OLDER ADULT MEN WITH DIABETES MELLITUS

BARRETT-CONNOR, E., KHAW, K.-T., YEN, S. S. C.·1990·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a115732
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Abstract

In a Southern California population-based cohort of 985 men aged 40-79 years in 1972-1974, 110 men with diabetes had significantly lower mean levels of endogenous plasma testosterone and sex hormone-binding globulin than did 875 nondiabetic men. Mean androstenedione, estrone, and estradiol levels did not differ significantly by diabetic status. The testosterone and sex hormone-binding globulin differences were reduced but not eliminated after adjustment for age and body mass index (weight (kg)/height (m)2). Twenty-one percent of diabetic men compared with 13% of nondiabetic men had testosterone levels below a categorically defined normal level of 3,500 pg/ml. Testosterone was inversely related to degree of glycemia in the whole cohort. Throughout the whole range of plasma glucose, there was a stepwise decrease in mean testosterone levels per categorical increase in fasting plasma glucose, apparent in both diabetics and nondiabetics. The clinical and physiologic implications of the reduced testosterone levels in diabetic men merit further investigation.

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Crossref · 10.1093/oxfordjournals.aje.a115732

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Metadata

Authors
BARRETT-CONNOR, E., KHAW, K.-T., & YEN, S. S. C.
Affiliations
University of California San Diego (US)
Corresponding author
BARRETT-CONNOR, E.
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
1990-11
Volume
132
Issue
5
Pages
895-901
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a115732
OpenAlex
W1957056004
Cited by
217
References
0
Citations by year
2026: 3 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 7
FWCI
2.83
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl034591-02, 5r01am031801-03)
  • National Heart, Lung, and Blood Institute (HL 34591, HV-1-2160-L)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
diabetes mellitus, testosterone, sex hormone-binding globulin, androstenedione, estrone, estradiol, older men, fasting blood glucose, glycemia, body mass index, hypogonadism
MeSH terms
Adult, Aged, Blood Glucose, Blood Pressure, Cholesterol, Diabetes Mellitus, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index

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