Cyproterone acetate: hepatoxicity and prostatic cancer treatment
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CPA has been associated with fatal liver toxicity.
“CPA has been associated with fatal liver toxicity (Parys 1991; Roila 1993).”
From Pharmacological interventions for those who have sexually offended or are at risk of offending (2015) · cites this paper as Roila 1993
Cites
High 10-Year Survival Rate in Patients With Early, Untreated Prostatic Cancer
Johansson, J. (1992) · JAMA · doi:10.1001/jama.1992.03480160049033 · Cited by 467 · see citing works
Severe hepatocellular dysfunction following cyproterone acetate therapy
PARYS, B. T., HAMID, S., & THOMSON, R. G. N. (1991) · British Journal of Urology · doi:10.1111/j.1464-410x.1991.tb15142.x · Cited by 39 · see citing works
Severe hepatitis caused by cyproterone acetate.
Blake, J. C., Sawyerr, A. M., Dooley, J. S., Scheuer, P. J., & McIntyre, N. (1990) · Gut · doi:10.1136/gut.31.5.556 · Cited by 38 · see citing works
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1 of the 4 references couldn’t be matched to a known paper.
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Pharmacological interventions for those who have sexually offended or are at risk of offending
Khan, O., Ferriter, M., Huband, N., Powney, M. J., Dennis, J. A., & Duggan, C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007989.pub2 · Cited by 144 · see citing works
Hepatotoxicity Induced by Antiandrogens: A Review of the Literature
Thole, Z., Manso, G., Salgueiro, E., Revuelta, P., & Hidalgo, A. (2004) · Urologia Internationalis · doi:10.1159/000081585 · Cited by 84 · see citing works
Barradell, L. B., & Faulds, D. M. (1994) · Drugs & Aging · doi:10.2165/00002512-199405010-00006 · Cited by 61 · see citing works
Bessone, F., Lucena, M., Roma, M. G., Stephens, C. M., Medina‐Cáliz, I., Frider, B., Tsariktsian, G., Hernández, N., Bruguera, M., Gualano, G., et al. (2015) · Liver International · doi:10.1111/liv.12899 · Cited by 60 · see citing works
Hepatotoxicity induced by cyproterone acetate: A report of three cases
Savidou, I. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i46.7551 · Cited by 46 · see citing works
Reilly, D. R., Delva, N. J., & Hudson, R. W. (2000) · The Canadian Journal of Psychiatry · doi:10.1177/070674370004500608 · Cited by 42 · see citing works
Case Report: Fatal Fulminant Hepatic Failure due to Cyproterone Acetate
Friedman, G., Lamoureux, E., & Sherker, A. H. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026639432428 · Cited by 36 · see citing works
Dose Adaptation of Antineoplastic Drugs in Patients with Liver Disease
Tchambaz, L., Schlatter, C., Jakob, M., hl-Melcher, A. K. H., Wolf, P. S., & hl, S. K. H. (2006) · Drug Safety · doi:10.2165/00002018-200629060-00004 · Cited by 26 · see citing works
Endocrine treatment of hepatocellular carcinoma. Any evidence of benefit?
Pignata, S., Daniele, B., Gallo, C., Vivo, R. D., Monfardini, S., & Perrone, F. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00317-1 · Cited by 23 · see citing works
Follow-Up Study of Children with Precocious Puberty Treated with Cyproterone Acetate
Watanabe, S., Cui, Y., Tanae, A., Tanaka, T., Fujimoto, M., Matsuo, Y., Tachibana, K., & Yamasaki, S. (1997) · Journal of Epidemiology · doi:10.2188/jea.7.173 · Cited by 12 · see citing works
Treatment of androgen excess in females: Yesterday, today and tomorrow
Pucci, E., & Petraglia, F. (1997) · Gynecological Endocrinology · doi:10.3109/09513599709152569 · Cited by 11 · see citing works
American Sexual Offender Castration Treatment and Legislation
del Busto, E., & Harlow, M. C. (2011) · Wiley eBooks · doi:10.1002/9781119990420.ch29 · Cited by 10 · see citing works
Pharmacological interventions for those who have sexually offended or are at risk of offending
Khan, O., Ferriter, M., Huband, N., & Smailagic, N. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007989 · Cited by 10 · see citing works
Cyproterone-Induced Hepatotoxicity
Pinganaud, G., Chaslerie, A., Bourdel‐Marchasson, I., Décamps, A., Manciet, G., & Emeriau, J. (1995) · Annals of Pharmacotherapy · doi:10.1177/106002809502900619 · Cited by 8 · see citing works
Kim, B., Kim, D. J., Sohn, K. M., Yang, H., Choi, M.-J., Lee, C., & Choi, K. (2009) · The Korean Journal of Internal Medicine · Cited by 1 · see citing works
The Liver in Urogenital Diseases
Guevara, M., Arroyo, V., & Rodés, J. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch20f · Cited by 1 · see citing works
Dose Adaptation of Drugs in Patients with Liver Disease
Fakultät, P.-N. (2004)
&NA; (1993) · Reactions Weekly · doi:10.2165/00128415-199304750-00025
- Authors
- Roila, F., Crinò, L., Carloni, G., & Natalini, G.
- Affiliations
- Azienda Ospedaliera di Perugia (IT)
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 4
- Issue
- 8
- Pages
- 701
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2588231264
- Cited by
- 19
- References
- 4
- Citations by year
- 2015: 2 · 2012: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Keywords
- cyproterone acetate, hepatotoxicity, prostate cancer, androgen deprivation therapy, drug-induced liver injury
- MeSH terms
- Aged, Humans, Liver, Male, Prostatic Neoplasms, Cyproterone Acetate, Chemical and Drug Induced Liver Injury
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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