Herpes virus-based vectors
Abstract
Herpesviruses are a diverse family of large DNA viruses, all of which have the capacity to establish lifelong latent infections. Many different herpesviruses may have potential as gene delivery vehicles, but exploitation of this potential has, to date, been explored only using Herpes simplex virus (HSV), a virus which naturally establishes a silent, latent infection of neurones in man and in a number of experimental animal models. Delivery of reporter genes in vitro and in vivo has been demonstrated using a variety of replication competent and replication defective vectors, and significant physiological modification in the CNS has been achieved by HSV-mediated gene delivery. Much remains to be done using animal models and, in particular, the requirements for long-term gene expression from latent virus genomes needs to be defined in different cell types in vivo.
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Deletion of genes necessary for the lytic cycle of HSV can create less toxic, replication-defective vectors that elicit a smaller immune response than wild-type HSV vectors.
“In a second system, the deletion of genes necessary for the lytic cycle of HSV can create less toxic, replication-defective vectors that elicit a smaller immune response than wild-type HSV vectors.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [112]
Deleting various combinations of the immediate, early genes that otherwise lead to the expression of the HSV infected cell proteins (ICP0, ICP4, ICP22, ICP27, and ICP47) creates several versions of replication-defective HSV vectors.
“Deleting various combinations of the immediate, early genes that otherwise lead to the expression of the HSV infected cell proteins (ICP0, ICP4, ICP22, ICP27, and ICP47) creates several versions of replication-defective HSV vectors.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [112]
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- Authors
- Efstathiou, S., & Minson, A. C.
- Affiliations
- University of Cambridge (GB)
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-01
- Volume
- 51
- Issue
- 1
- Pages
- 45-55
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2443887951
- Cited by
- 32
- References
- 0
- Citations by year
- 2026: 2 · 2020: 1 · 2016: 2 · 2013: 1
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Medical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- herpesvirus vectors, herpes simplex virus, gene delivery, gene therapy, latent infection, replication-defective vectors, reporter genes, central nervous system gene expression, long-term gene expression, animal models
- MeSH terms
- Genetic Vectors, Humans, Genetic Therapy, Virus Latency, Gene Transfer Techniques, Simplexvirus
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