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Andrology: Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia
Abstract
Globozoospermia or round-headed spermatozoa is a rare type of teratozoospermia where the acrosome is absent resulting in male infertility with no known therapy. A few studies have shown that round-headed spermatozoa cannot bind to or penetrate the zona pellucida, and no normal fertilization has been observed in in-vitro fertilization (IVF) after insemination of human oocytes with round-headed spermatozoa. In this study, the fertilization capacity of round-headed spermatozoa after intracytoplasmic sperm injection (ICSI) into human oocytes has been examined. In pre-clinical experiments, 45 oocytes were injected; 41 oocytes were intact after injection, 15 oocytes were fertilized normally, and 13 of these 15 oocytes developed further in vitro. ICSI was carried out in 11 treatment cycles of seven infertile couples with globozoospermia. Normal fertilization and embryo transfer occurred in four cycles (three patients). Positive serum human chorionic gonadotrophin was observed in three cycles (two patients); one patient had a pre-clinical abortion and the other patient became pregnant twice; the first pregnancy was ectopic and the second pregnancy is a twin pregnancy which is currently at 16 weeks of gestation.
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“Globozoospermic men were infertile and some were able to achieve a pregnancy after ICSI.”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [30]
In the citing paper
“Success rates of ICSI remain rather low, with many failures or with lower fertilisation rates [30, 31, 32, 33].”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [30]
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The biology of infertility: research advances and clinical challenges
Matzuk, M. M., & Lamb, D. J. (2008) · Nature Medicine · doi:10.1038/nm.f.1895 · Cited by 948
Real‐Time Fine Morphology of Motile Human Sperm Cells is Associated With IVF‐ICSI Outcome
BARTOOV, B., Berkovitz, A., Eltes, F., Kogosowski, A., Menezo, Y. J. R., & Barak, Y. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02595.x · Cited by 425
Chemes, H. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg034 · Cited by 291
Dam, A. H. D. M., Feenstra, I., Westphal, J. R., Ramos, L., van Golde, R. J. T., & Kremer, J. A. M. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml047 · Cited by 270
Oocyte activation, phospholipase C zeta and human infertility
Kashir, J., Heindryckx, B., Jones, C., Sutter, P. D., Parrington, J., & Coward, K. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq018 · Cited by 267
Metadata
- Authors
- Liu, J., Nagy, Z., Joris, H., Tournaye, H., Devroey, P., & Van Steirteghem, A.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-03
- Volume
- 10
- Issue
- 3
- Pages
- 626-629
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2253903664
- Cited by
- 138
- References
- 0
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 11
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- globozoospermia, intracytoplasmic sperm injection, sperm fertility, male infertility, teratozoospermia, embryonic development, pregnancy outcomes, ectopic pregnancy, twin pregnancy
- MeSH terms
- Acrosome, Adult, Cytoplasm, Embryo Transfer, Female, Fertilization in Vitro, Chorionic Gonadotropin, Humans, Infertility, Male, Male, Microinjections, Middle Aged, Oocytes, Pregnancy, Spermatozoa
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