Immunology: Bone marrow-derived cell populations in uterine and ectopic endometrium
Abstract
Uterine endometrium contains numerous bone marrow-derived cells. The spectrum of cell types is different from that of any other tissue, and the differences in endometrium from women with endometriosis may reflect a different endometrial phenotype in these women. The cell types of bone marrow origin found in ectopic endometrium may indicate the degree of differentiation of the tissue. It was found that, in normal endometrium, the CD45+ cell population comprised T cells, macrophages, CD56+ large granular lymphocytes, some CD16+ cells and a few B cells. Changes in these cell populations during the menstrual cycle were similar in endometrium from both controls and patients with endometriosis, and resembled that reported previously by others. In ectopic endometrium, the frequency of CD45+ cells remained within the same range as that of uterine endometrium but without any obvious pattern of change during the menstrual cycle. CD56+ large granular lymphocytes, an immune cell type characteristic of uterine endometrium, were also found in ectopic endometrium. Our results indicate that ectopic endometrium, as well as comprising both glandular and stromal cells, contains bone marrow-derived cell populations similar to those of uterine endometrium. This suggests that the same processes of cell migration and/or differentiation occur in ectopic and uterine endometrium.
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Some mesenchymal/mesothelial cells of the peritoneal cavity, of mesothelial repair after surgery, and in endometrium and endometriosis are directly derived from bone marrow.
“Some of these mesenchymal/ mesothelial cells of the peritoneal cavity (48), of the mesothelial repair after surgery (126) and in endometrium and endometriosis (127-131) are directly derived from bone marrow.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [127]
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- Authors
- Fernandez-Shaw, S., Clarke, M. T., Hicks, B., Naish, C. E., Barlow, D. H., & Starkey, P. M.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-09-01
- Volume
- 10
- Issue
- 9
- Pages
- 2285-2289
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2104571693
- Cited by
- 34
- References
- 0
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, ectopic endometrium, endometrium, bone marrow-derived cells, CD45-positive cells, T cells, macrophages, CD16+ cells, B cells, menstrual cycle, cell migration
- MeSH terms
- B-Lymphocytes, Bone Marrow, Cell Differentiation, Endometriosis, Endometrium, Female, Humans, Immunohistochemistry, Lymphocytes, Macrophages, T-Lymphocytes, Uterus, Receptors, IgG, Leukocyte Common Antigens, Premenopause, Lymphocyte Count, CD56 Antigen
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