The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Functional Role of Glycosphingolipids in Cell Recognition and Signaling
Abstract
Glycosphingolipids (GSLs), cell type-specific markers which change dramatically during ontogenesis and oncogenesis, have been implicated as playing major roles in cellular interactions and control of cell proliferation in multicellular organisms. These functional roles have been partially clarified through two types of studies: (i) Studies of cell recognition mediated by (a) GSL-GSL interaction, (b) GSL-lectin interaction, and (c) GSL-dependent modulation of integrin receptor function. (ii) Studies on control of transmembrane signaling by GSLs and/or sphingosine (Sph) derivatives, with emphasis on effects of these compounds on: (a) signaling pathways initiated by tyrosine kinase-linked receptors; (b) signaling systems mediated by protein kinase C, MAP kinase, other kinases, or cytosolic Ca2+ concentration, leading to changes in cellular phenotypes such as motility, proliferation, differentiation, and apoptosis.
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Cites
Varki, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7390 · Cited by 946
Bremer, E. G., Schlessinger, J., & Hakomori, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35954-9 · Cited by 706
Self-citationZhou, Q., Hakomori, S., Kitamura, K., & Igarashi, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42121-1 · Cited by 131
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Cited by
A vital role for glycosphingolipid synthesis during development and differentiation
Yamashita, T., Wada, R., Sasaki, T., Deng, C., Bierfreund, U., Sandhoff, K., & Proia, R. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9142 · Cited by 505
Ganglioside GM3 Participates in the Pathological Conditions of Insulin Resistance
Tagami, S., Inokuchi, J.-I., Kabayama, K., Yoshimura, H., Kitamura, F., Uemura, S., Ogawa, C., Ishii, A., Saito, M., Ohtsuka, Y., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m103705200 · Cited by 355
Self-citationYoon, S.-J., Nakayama, K.-I., Hikita, T., Handa, K., & Hakomori, S.-I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609281103 · Cited by 210
Self-citationTrends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry
Dehelean, L., Sarbu, M., Petrut, A., & Zamfir, A. D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-15950-4_42 · Cited by 16
Botcha, L., Sehar, M., Cheng, Y.-C., Zhang, S.-C., Khan Jadoon, M. S., & Chuang, P.-K. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108464 · Cited by 1
Metadata
- Authors
- Hakomori, S.-I., & Igarashi, Y.
- Venue
- The Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-12
- Volume
- 118
- Issue
- 6
- Pages
- 1091-1103
- ISSN
- 0021-924X (ISSN-L)
- 1756-2651
- OpenAlex
- W2166371391
- Cited by
- 395
- References
- 3
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hakomori, S.-I., & Igarashi, Y. (1995). Functional Role of Glycosphingolipids in Cell Recognition and Signaling. The Journal of Biochemistry. https://doi.org/10.1093/oxfordjournals.jbchem.a124992
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