Cited by 16Metabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and ApplicationsSphingolipid Metabolism and Signaling

Trends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry

Dehelean, Liana, Sarbu, Mirela, Petrut, Alina, Zamfir, Alina D.·2019·Advances in experimental medicine and biology

Abstract

Considering the devastating effects of neurodegenerative disorders and the increasing number of people affected by them, an early diagnosis even presymptomatic, prior to serious mental deterioration is necessary. Therefore, screening for biomarkers, especially glycolipids, in the biological matrices, either tissues or body fluids has proven to be of a great help in establishing an early diagnosis of the disease.The present chapter, divided into three parts, highlights the implementation and modern applications of the most avant-garde mass spectrometry (MS) techniques characterized by speed, sensitivity and data accuracy for de novo identification and monitoring of glycolipids with potential biomarker role. The first section reviews the etiology, epidemiology, clinical picture, as well as the current diagnostic methods for four of the most frequent neurodegenerative disorders: Parkinson's disease, Alzheimer's disease, Lewy body dementia and fronto-temporal dementia. The second section is dedicated to the role of glycolipids as biomarkers of these severe conditions. In the last part of the chapter, the state of the art in terms of mass spectrometry techniques for the detection of extremely valuable glycolipid biomarkers is described in detail. The proficiency of the MS, to be considered as and further developed into a routine method for early detection of neurodegenerative disorders, is also emphasized in the chapter.

Integrity signals

Registry

Crossref · 10.1007/978-3-030-15950-4_42

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dehelean, L., Sarbu, M., Petrut, A., & Zamfir, A. D.
Affiliations
  • Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
  • National Institute of Research and Development for Electrochemistry and Condensed (RO)
Corresponding author
Dehelean, Liana
Venue
Advances in experimental medicine and biology
Published
2019
Volume
1140
Pages
703-729
ISSN
  • 0065-2598 (ISSN-L)
  • 2214-8019
OpenAlex
W2963175287
Cited by
16
References
146
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 2
FWCI
3.42
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
glycolipids, biomarkers, neurodegenerative diseases, early diagnosis, Parkinson's disease, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, mass spectrometry, biological fluids, disease screening
MeSH terms
Glycolipids, Humans, Mass Spectrometry, Biomarkers, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review