Cited by 108Viral Infections and Outbreaks ResearchEvolution and Genetic DynamicsVirology and Viral Diseases

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The origin and evolution of Ebola and Marburg viruses

Suzuki, Y., Gojobori, T.·1997·Molecular Biology and Evolution

DOI 10.1093/oxfordjournals.molbev.a025820

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Abstract

Molecular evolutionary analyses for Ebola and Marburg viruses were conducted with the aim of elucidating evolutionary features of these viruses. In particular, the rate of nonsynonymous substitutions for the glycoprotein gene of Ebola virus was estimated to be, on the average, 3.6 x 10(-5) per site per year. Marburg virus was also suggested to be evolving at a similar rate. Those rates were a hundred times slower than those of retroviruses and human influenza A virus, but were of the same order of magnitude as that of the hepatitis B virus. When these rates were applied to the degree of sequence divergence, the divergence time between Ebola and Marburg viruses was estimated to be more than several thousand years ago. Moreover, most of the nucleotide substitutions were transitions and synonymous for Marburg virus. This suggests that purifying selection has operated on Marburg virus during evolution.

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Authors: Suzuki, Y., & Gojobori, T.
Affiliations: National Institute of Genetics (JP)
ORCID: Suzuki, Y.
Gojobori, T.
Venue: Molecular Biology and Evolution
Publisher: Oxford University Press (OUP)
Published: 1997-08-01
Volume: 14
Issue: 8
Pages: 800-806
ISSN: 0737-4038 (ISSN-L)
1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025820
OpenAlex: W2121586109
Semantic Scholar: 84b21893b7d878d9111c32cb040e7e5af019cceb
Cited by: 108
References: 37
Citations by year: 2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 17 · 2014: 9 · 2013: 2 · 2012: 7
FWCI: 0.84
Type: journal article
Language: en
Open access: closed
Locations: Molecular Biology and Evolution (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute
Topics: Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: Ebola virus, Marburg virus, molecular evolution, nonsynonymous substitution rate, glycoprotein gene, divergence time estimation, purifying selection, nucleotide substitution patterns, sequence divergence
MeSH terms: DNA, Viral, Genes, Viral, Molecular Sequence Data, Mutation, Viral Proteins, Viral Structural Proteins, Filoviridae, Evolution, Molecular, Marburgvirus, Ebolavirus

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The origin and evolution of Ebola and Marburg viruses

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