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Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.
Open accessAbstract
A phylogenetic analysis of sex-chromosomal zinc-finger genes (Zfx and Zfy) indicates that the genes have not evolved completely independently since their initial separation. The sequence similarities suggest gene conversion in the last exon between the duplicated Y-chromosomal genes Zfy-1 and Zfy-2 in the mouse. There are also indications of conversion (or recombination) between the X- and Y-chromosomal genes in the crab-eating fox and in the mouse. The method for estimating synonymous and nonsynonymous substitutions is modified by incorporating the substitutions in the twofold-degenerate sites in a novel way. The estimates of synonymous substitutions support the generation-time hypothesis in that the obtained rates are higher in mice (by a factor of 4.7) than in humans and higher in the Y-chromosomal genes (by a factor of 1.9) than in the X-chromosomal genes.
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Citations
Cited by
PAML 4: Phylogenetic Analysis by Maximum Likelihood
Yang, Z. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm088 · Cited by 13,879
Jaillon, O., Aury, J.-M., Brunet, F., Petit, J.-L., Stange-Thomann, N., Mauceli, E., Bouneau, L., Fischer, C., Ozouf-Costaz, C., Bernot, A., et al. (2004) · Nature · doi:10.1038/nature03025 · Cited by 1,966
A codon-based model of nucleotide substitution for protein-coding DNA sequences.
(1994) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040153 · Cited by 1,960
Estimating Synonymous and Nonsynonymous Substitution Rates Under Realistic Evolutionary Models
Yang, Z., & Nielsen, R. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026236 · Cited by 1,764
Unbiased estimation of the rates of synonymous and nonsynonymous substitution
Li, W.-H. (1993) · Journal of Molecular Evolution · doi:10.1007/bf02407308 · Cited by 1,080
Metadata
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-03
- Volume
- 10
- Issue
- 2
- Pages
- 271-81
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W1898801155
- Cited by
- 505
- References
- 0
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Evolution of the Zfx and Zfy genes: rates and interdependence between the genes. (1993). Molecular Biology and Evolution. https://doi.org/10.1093/oxfordjournals.molbev.a040003
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