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Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.

Open access
·1993·Molecular Biology and Evolution

Abstract

A phylogenetic analysis of sex-chromosomal zinc-finger genes (Zfx and Zfy) indicates that the genes have not evolved completely independently since their initial separation. The sequence similarities suggest gene conversion in the last exon between the duplicated Y-chromosomal genes Zfy-1 and Zfy-2 in the mouse. There are also indications of conversion (or recombination) between the X- and Y-chromosomal genes in the crab-eating fox and in the mouse. The method for estimating synonymous and nonsynonymous substitutions is modified by incorporating the substitutions in the twofold-degenerate sites in a novel way. The estimates of synonymous substitutions support the generation-time hypothesis in that the obtained rates are higher in mice (by a factor of 4.7) than in humans and higher in the Y-chromosomal genes (by a factor of 1.9) than in the X-chromosomal genes.

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Metadata

Venue
Molecular Biology and Evolution
Published
1993-03
Volume
10
Issue
2
Pages
271-81
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
OpenAlex
W1898801155
Cited by
505
References
0
FWCI
6.07
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Evolution of the Zfx and Zfy genes: rates and interdependence between the genes. https://app.cochat.ai/papers/10.1093/oxfordjournals.molbev.a040003
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Evolution of the Zfx and Zfy genes: rates and interdependence between the genes. (1993). Molecular Biology and Evolution. https://doi.org/10.1093/oxfordjournals.molbev.a040003

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