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Positive darwinian selection observed at the variable-region genes of immunoglobulins.
Abstract
To examine Gojobori and Nei's hypothesis that the immunoglobulin heavy-chain variable-region (VH) genes in mammals are subject to diversity-enhancing selection, we studied the rates of synonymous and nonsynonymous nucleotide substitution in the complementarity-determining regions (CDRs) and in the framework regions (FRs) of mouse and human VH genes. The results obtained indicate that the non-synonymous rate is higher than the synonymous rate in CDRs, whereas the reverse is true in FRs. This observation supports Gojobori and Nei's hypothesis and suggests that diversity-enhancing selection (similar to overdominant selection) operates mainly in CDRs and that this is one of the evolutionary factors that increase antibody diversity.
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Citations
Cited by
Evolution by gene duplication: An update
Zhang, J. (2003) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(03)00033-8 · Cited by 2,201
Detecting Individual Sites Subject to Episodic Diversifying Selection
Murrell, B., Wertheim, J. O., Moola, S., Weighill, T., Scheffler, K., & Kosakovsky Pond, S. L. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002764 · Cited by 1,811
PHYLOGENETIC ANALYSIS IN MOLECULAR EVOLUTIONARY GENETICS
Nei, M. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.371 · Cited by 349
Self-citationThe life and death of gene families
Demuth, J. P., & Hahn, M. W. (2009) · BioEssays · doi:10.1002/bies.080085 · Cited by 311
Where Are the Disease-Associated eQTLs?
Umans, B. D., Battle, A., & Gilad, Y. (2021) · Trends in Genetics · doi:10.1016/j.tig.2020.08.009 · Cited by 296
Metadata
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-09
- Volume
- 6
- Issue
- 5
- Pages
- 447-59
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2170288714
- Cited by
- 208
- References
- 0
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Positive darwinian selection observed at the variable-region genes of immunoglobulins. (1989). Molecular Biology and Evolution. https://doi.org/10.1093/oxfordjournals.molbev.a040569
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