Early life environment and social determinants of cardiac health in children with congenital heart disease
Open accessAbstract
Congenital heart disease is a significant cause of infant mortality. Epidemiology and social context play a crucial role in conditioning disease burden and modulating outcomes, while diagnosis and treatment remain resource intensive. This review will address the role of social demographics, environmental exposure, epigenetics and nutrition in the aetiology of congenital heart disease. We then discuss the determinant effect of social factors on the provision and outcomes of care for congenital heart disease and implications for practice. It is our hope that enhanced knowledge of the intersection of social determinants of health and congenital heart disease will facilitate effective preventative strategies at the individual and population levels to optimize heart health outcomes across the life course.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The association between socioeconomic factors and neurodevelopment status has not been extensively studied in patients with TOF.
“the association between socioeconomic factors and neurodevelopment status has not been extensively studied in patients with TOF [13–15].”
From Early Evaluation and the Effect of Socioeconomic Factors on Neurodevelopment in Infants with Tetralogy of Fallot. (2021) · cites this paper as [13]
The intrauterine life-stage section mentions TOF in relation to congenital heart disease prevalence and reproductive technology, not neurodevelopmental status. Searches for neurodevelopmental outcomes and limited research found no passage assessing how extensively socioeconomic factors and neurodevelopment in patients with TOF have been studied. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Birth prevalence of congenital heart disease worldwide
van der Linde, D., Konings, E. E. M., Slager, M. A., Witsenburg, M., Helbing, W. A., Takkenberg, J. J. M., & Roos-Hesselink, J. W. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.025 · Cited by 3,452 · see citing works
Ben-Shlomo, Y. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.2.285 · Cited by 3,038 · see citing works
Killing Me Softly: The Fetal Origins Hypothesis
Almond, D. V., & Currie, J. (2011) · The Journal of Economic Perspectives · doi:10.1257/jep.25.3.153 · Cited by 1,617 · see citing works
Poverty and Child Health in the United States
Gitterman, B. A., Flanagan, P., Cotton, W. H., Dilley, K. J., Duffee, J. H., Green, A. E., Keane, V. A., Krugman, S., Linton, J. M., McKelvey, C. D., et al. (2016) · PEDIATRICS · doi:10.1542/peds.2016-0339 · Cited by 771 · see citing works
Congenital Heart Defects in the United States
Gilboa, S. M., Devine, O. J., Kucik, J. E., Oster, M. E., Riehle‐Colarusso, T. J., Nembhard, W. N., Xu, P., Correa, A., Jenkins, K. J., & Marelli, A. J. (2016) · Circulation · doi:10.1161/circulationaha.115.019307 · Cited by 705 · see citing works
Racial and Temporal Variations in the Prevalence of Heart Defects
Botto, L. D., Correa, A., & Erickson, J. D. (2001) · PEDIATRICS · doi:10.1542/peds.107.3.e32 · Cited by 567 · see citing works
Fetal nutrition and cardiovascular disease in later life
Barker, D. J. P. (1997) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011609 · Cited by 373 · see citing works
Prenatal Multivitamin Supplementation and Rates of Congenital Anomalies: A Meta-Analysis
Goh, Y. I., Bollano, E., Einarson, T. R., & Koren, G. (2006) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32227-7 · Cited by 269 · see citing works
Epigenetics and Cardiovascular Development
Chang, C., & Bruneau, B. G. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153242 · Cited by 202 · see citing works
Kelishadi, R., & Poursafa, P. (2014) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2013.12.005 · Cited by 155 · see citing works
Maternal Smoking and Congenital Heart Defects in the Baltimore-Washington Infant Study
Alverson, C. J., Strickland, M. J., Gilboa, S. M., & Correa, A. (2011) · PEDIATRICS · doi:10.1542/peds.2010-1399 · Cited by 148 · see citing works
Metabolic Syndrome in Adults With Congenital Heart Disease
Deen, J. F., Krieger, E. V., Slee, A. E., Arslan, A., Arterburn, D. E., Stout, K., & Portman, M. A. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.114.001132 · Cited by 113 · see citing works
Ambient air pollution and congenital heart disease: a register-based study.
Dadvand, P., Rankin, J., Rushton, S., & Pless-mulloli, T. (2011) · Environmental Research · doi:10.1016/j.envres.2011.01.022 · Cited by 112 · see citing works
Tararbit, K., Houyel, L., Bonnet, D., Vigan, C. D., Lelong, N., Goffinet, F., & Khoshnood, B. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq440 · Cited by 109 · see citing works
Potential Effects of Environmental Chemical Contamination in Congenital Heart Disease
Gorini, F., Chiappa, E., Gargani, L., & Picano, E. (2014) · Pediatric Cardiology · doi:10.1007/s00246-014-0870-1 · Cited by 86 · see citing works
Neurodevelopmental outcomes after congenital heart surgery and strategies for improvement
Tabbutt, S., Gaynor, J. W., & Newburger, J. W. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328350197b · Cited by 76 · see citing works
Neighbourhoods and child adiposity: A critical appraisal of the literature
Carter, M. A., & Dubois, L. (2010) · Health & Place · doi:10.1016/j.healthplace.2009.12.012 · Cited by 74 · see citing works
Maternal Folate-Related Gene Environment Interactions and Congenital Heart Defects
Hobbs, C. A., Cleves, M. A., Karim, M. A., Zhao, W., & MacLeod, S. L. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181e80979 · Cited by 67 · see citing works
Agha, M. M., Glazier, R. H., Moineddin, R., Moore, A. M., & Guttmann, A. (2011) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.22857 · Cited by 58 · see citing works
Self-citationSmedts, H. P. M., van Uitert, E. M., Valkenburg, O., Laven, J. S. E., Eijkemans, M. J. C., Lindemans, J. W., Steegers, E. A. P., & Steegers‐Theunissen, R. P. M. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.07.016 · Cited by 55 · see citing works
Pediatric Adverse Childhood Experiences: Implications for Life Course Health Trajectories
Szilagyi, M. A., & Halfon, N. (2015) · Academic Pediatrics · doi:10.1016/j.acap.2015.07.004 · Cited by 51 · see citing works
Schickedanz, A. B., Dreyer, B. P., & Halfon, N. (2015) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2015.05.008 · Cited by 46 · see citing works
Botto, L. D., Krikov, S. V., Carmichael, S. L., Munger, R. G., Shaw, G. M., & Feldkamp, M. L. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2014-308013 · Cited by 46 · see citing works
Overweight Adolescents and Life Events in Childhood
Lumeng, J. C., Wendorf, K. A., Pesch, M. H., Appugliese, D. P., Kaciroti, N., CORWYN, R. F., & Bradley, R. H. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1111 · Cited by 42 · see citing works
Fazalullasha, F., Taras, J., Morinis, J., Levin, L., Karmali, K., Neilson, B., Muskat, B., Bloch, G. C., Chan, K., McDonald, M., et al. (2014) · Paediatrics & Child Health · doi:10.1093/pch/19.4.195 · Cited by 32 · see citing works
Self-citationSocioeconomic Influences on Child Health
Halfon, N. (2014) · JAMA · doi:10.1001/jama.2014.608 · Cited by 28 · see citing works
Abe, S., Nakae, J., Yasoshima, K., Tajima, T., Shinohara, N., Murashita, M. M., Satoh, K., Koike, A., Takahashi, Y., & Fujieda, K. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990521)84:2 · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [8]8. Lin AE, Herring AH, Amstutz KS, et al. Cardiovascular malforma- tions: Changes in prevalence and birth status, 1972-1990. Am J Med Genet 1999;84(2):102-10.
- [11]11. Chang CP, Bruneau BG. Epigenetics and cardiovascular develop- ment. Annu Rev Physiol 2012;74:41-68.
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987 · see citing works
Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784 · see citing works
Lopez, K. N., Baker-Smith, C. M., Flores, G., Gurvitz, M. Z., Karamlou, T., Gallegos, F. N., Pasquali, S. K., Patel, A., Peterson, J. K., Salemi, J. L., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025358 · Cited by 146 · see citing works
Lifespan Perspective on Congenital Heart Disease Research
Diller, G., Arvanitaki, A., Opotowsky, A. R., Jenkins, K. J., Moons, P., Kempny, A., Tandon, A. A., Redington, A. N., Khairy, P., Mital, S. R., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.03.012 · Cited by 114 · see citing works
The Role of Abnormal Placentation in Congenital Heart Disease; Cause, Correlate, or Consequence?
Courtney, J. A., Cnota, J. F., & Jones, H. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01045 · Cited by 95 · see citing works
Congenital heart disease in low‐and‐middle‐income countries: Focus on sub‐Saharan Africa
Zimmerman, M. S., & Sable, C. (2020) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31769 · Cited by 68 · see citing works
Exposome and Social Vulnerability: An Overview of the Literature Review
Deguen, S., Amuzu, M., Simoncic, V., & Kihal, W. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063534 · Cited by 57 · see citing works
The Role of Non-Coding RNA in Congenital Heart Diseases
Dueñas, Á., Expósito, A., Aránega, A. E., & Franco, D. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6020015 · Cited by 43 · see citing works
Experimental Rodent Models of Cardiovascular Diseases
Jia, T., Wang, C., Han, Z., Wang, X., Ding, M., & Wang, Q. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.588075 · Cited by 42 · see citing works
Analysis of Biomarkers for Congenital Heart Disease Based on Maternal Amniotic Fluid Metabolomics
Li, Y., Sun, Y., Yang, L., Huang, M., Zhang, X., Wang, X., Guan, X., Yang, P., Wang, Y., Meng, L., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.671191 · Cited by 38 · see citing works
Favilla, E., Faerber, J. A., Hampton, L. E., Tam, V., DeCost, G., Ravishankar, C., Gaynor, J. W., Burnham, A., Licht, D. J., & Mercer-Rosa, L. (2021) · Pediatric Cardiology · doi:10.1007/s00246-020-02525-6 · Cited by 33 · see citing works
“Social and economic drivers have a known influence on multiple facets of CHD outcomes from birth through childhood [13, 25].”
BackgroundDNA methylation abnormalities of imprinted genes in congenital heart disease: a pilot study
Chang, S., Wang, Y., Xin, Y., Wang, S., Luo, Y., Wang, L., Zhang, H., & Li, J. (2021) · BMC Medical Genomics · doi:10.1186/s12920-020-00848-0 · Cited by 27 · see citing works
Miao, Q., Dunn, S., Wen, S. W., Lougheed, J., Yang, P., Davies, M. J., Venegas, C. L., & WALKER, M. C. (2023) · BMC Public Health · doi:10.1186/s12889-023-15660-5 · Cited by 19 · see citing works
Social Determinants of Health and Hirschsprung-associated Enterocolitis
Knaus, M. E., Pendola, G., Srinivas, S., Wood, R. J., & Halaweish, I. F. (2022) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2022.09.039 · Cited by 18 · see citing works
Risk factors of congenital heart diseases: A hospital-based case-control study in Isfahan, Iran.
Ahmadi, A., Gharipour, M., Navabi, Z. S., & Heydari, H. (2020) · PubMed Central · doi:10.22122/arya.v16i1.1941 · Cited by 15 · see citing works
Socioeconomic inequality in congenital heart diseases in Iran
Rarani, M. A., Vahedi, S., Borjali, M., & Nosratabadi, M. (2021) · International Journal for Equity in Health · doi:10.1186/s12939-021-01591-3 · Cited by 16 · see citing works
Placental–Heart Axis: An Evolutionary Perspective
Matthews, J., Rajakumar, B., Carreon, C. K., & Morton, S. U. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011212 · Cited by 10 · see citing works
Borjali, M., Rarani, M. A., & Nosratabadi, M. (2021) · Cardiology Research and Practice · doi:10.1155/2021/6647260 · Cited by 6 · see citing works
Teng, C., Shu, D., Faerber, J., Goldenring, J., Butto, A., Tam, V. W., Olsen, R., Glatz, A. C., & Cohen, M. S. (2024) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2024.113901 · Cited by 5 · see citing works
Association of social determinants with the severity of congenital heart disease
Forero-Manzano, M. J., Triana-Palencia, E., Figueroa-Rueda, J. A., Flórez-Rodríguez, C. X., Castro, J., Quintero-Lesmes, D. C., & Gamboa-Delgado, E. M. (2022) · Pediatric Research · doi:10.1038/s41390-022-02205-6 · Cited by 4 · see citing works
Prevalence of congenital heart defects in assigned children for intercountry adoption
Oliván-Gonzalvo, G., & Gracia-Balaguer, J. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab022 · Cited by 3 · see citing works
Disparities in disease burden of congenital heart disease among 150,488 individuals in Western China
Wang, J., Bai, Y., Zhou, H., & Liu, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-91256-w · Cited by 1 · see citing works
Social inequities hurt babies’ hearts: a commentary on Forero-Manzano, MJ, et al.
Cláudio, L., Ortega-García, J. A., & Rodríguez-Villamizar, L. A. (2022) · Pediatric Research · doi:10.1038/s41390-022-02363-7
A REALIZAÇÃO DO PRÉ-NATAL NAS COMUNIDADES RURAIS
Goncalves, D. F., dos Santos, M. B., Rodrigues, M. E. C., Ricci, D. F., Silva, J. N., Luz, A. F., Rabelo, J. D. P., Cordeiro, A. P. D. S., Acatauassú, A. P., Bastos, A. L. B., et al. (2023) · doi:10.22533/at.ed.1112331082
A RELAÇÃO ENTRE A CATARATA E O DIABETES MELLITUS TIPO 2
Ranieri, A. M., Santos, J. V. D. M., Boti, G. A. S., Vidonho, S. L., Silva, F. A., de Almeida, M. L. C., Teixeira, N. A. S., da Silva, R. A. P., & Dias, Y. G. R. (2023) · doi:10.22533/at.ed.1112331084
Ruiz, M. E. P., Chapman, M. C. S., & Frómeta, R. L. (2023) · doi:10.22533/at.ed.11123310815
Bolaños, E. F. R., Flórez, N., & Héctor Mauricio Montilla, C. (2023) · doi:10.22533/at.ed.11123310810
Ciencias de la Salud: Aspectos diagnósticos y preventivos de enfermedades 3
Praxedes, M. F. D. S. (2023) · doi:10.22533/at.ed.111233108
A ASSISTÊNCIA EM SAÚDE PARA OS POVOS INDÍGENAS
Goncalves, D. F., Salgado, R. S., Pantoja, B. A., Neto, G. I. L., Araújo, C. B., Abucater, J. V. F. G., Viana, J. P., Silva, L. F., dos Santos, M. B., Gabriel, L. P., et al. (2023) · doi:10.22533/at.ed.1112331081
DETERMINACIÓN DE TÉCNICAS DIAGNÓSTICAS CONVENCIONALES Y NO CONVENCIONALES PARA GIARDIA SPP
Maza, N. S. H., Loayza, S. B. R., & Alberca, A. A. R. (2023) · doi:10.22533/at.ed.11123310812
RELACIÓN ENTRE FUNCIONES EJECUTIVAS Y EMPATÍA EN NIÑOS DE 9 A 11 AÑOS
Salinas, A., & Jiménez, X. A. O. (2023) · doi:10.22533/at.ed.11123310811
O USO DA ATROPINA NO CONTROLE DA PROGRESSÃO DA MIOPIA: EFICÁCIA E EFEITOS COLATERAIS
Fructuoso, A. C. V., Nogueira, P. P., Oliveira, G. D. S., Queiroz, P. H. L., Leal, D. L., Badaró, C. B., Lopes, F. G. C., de Andrade, L. M. C., Teixeira, P. P., Junqueira, J. D. P. C., et al. (2023) · doi:10.22533/at.ed.1112331085
REVISÃO DA LITERATURA SOBRE YOGA E MEDITAÇÃO EM PRISÕES
Videla, J. A. V. (2023) · doi:10.22533/at.ed.11123310817
O PROTAGONISMO DO DISCENTE NA EXTENSÃO UNIVERSITÁRIA: RELATO DE EXPERIÊNCIA
Ramos, M. M. S., Castro, F. B., Duarte, I. M., Ribeiro, L. V. S., de Eça, L. T. C., Ismerim, A. B., Andrade, R. D. C. D. V., & de Freitas, M. D. C. A. (2023) · doi:10.22533/at.ed.11123310819
A RELAÇÃO ENTRE O INFARTO AGUDO DO MIOCÁRDIO E A ARRITMIA
Santos, J. V. D. M., de Almeida, M. L. C., Nunes, V. M., Lobato, A. L. D. M., Silva, A. M. C., Linhares, J. N. C., Fernandes, B. D. M., Ferreira, P. D. O. A., Martins, C. D. M., Almeida, R. K., et al. (2023) · doi:10.22533/at.ed.1112331086
COMPUESTOS NUTRICIONALES Y BIOACTIVOS DE TRES TIPOS DE FRUTAS NATIVAS DEL PERÚ
Rosa, A. J. O.-L., & Rojas-Naccha, J. C. (2023) · doi:10.22533/at.ed.11123310816
BIOLOGICAL EVALUATION OF MITO-SG1 AS A POTENT CYTOTOXIC AGENT IN THE TREATMENT OF GASTRIC CANCER
Lineros-Franco, G. A., Bueno-Duarte, Y., Montoya-Villegas, J. C., Hardy, M., Ouari, O., López, M., & Sanabria, S. (2023) · doi:10.22533/at.ed.1112331087
EL ENCUADRE DEL MENSAJE EN SPOTS RADIOFÓNICOS DE LA FASE 2 DE COVID-19, EN MÉXICO
Guadalupe, L. G. A., & Guadalupe, A. M. M. (2023) · doi:10.22533/at.ed.1112331088
ADMINISTRAÇÃO SUBCUTÂNEA DE ANTIMICROBIANOS DE USO HOSPITALAR: PROTOCOLO DE REVISÃO
Figueiredo, T. W. D. C., Martins, M. A. P., de Almeida, C. D. C., & Praxedes, M. F. D. S. (2023) · doi:10.22533/at.ed.11123310820
SÍNTOMAS DEPRESIVOS EN ESTUDIANTES DE ENFERMERÍA
Ortiz, S. L. M., Gloria-Delgado, B. A., Loredo, C. P., Espinoza, E. A. C., & Robledo, F. R. M. (2023) · doi:10.22533/at.ed.11123310818
- Authors
- Wong, P., Denburg, A., Dave, M., Levin, L., Morinis, J. O., Suleman, S., Wong, J., Ford-Jones, E., & Moore, A. M.
- Affiliations
- University of Toronto (CA)
- Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario
- Corresponding author
- Moore, Aideen M
- Venue
- Paediatrics & Child Health
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-11-02
- Volume
- 23
- Issue
- 2
- Pages
- 92-95
- ISSN
- 1205-7088 (ISSN-L)
- 1918-1485
- PMC
- PMC5905484
- OpenAlex
- W2765748031
- Cited by
- 43
- References
- 27
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 20 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 1 · 2018: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Paediatrics & Child Health (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- congenital heart disease, social determinants of health, early life environment, environmental exposure, epigenetics, nutrition, etiology, health disparities, prevention, life course
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
