The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Arabidopsis TERMINAL FLOWER 2 Gene Encodes a Heterochromatin Protein 1 Homolog and Represses both FLOWERING LOCUS T to Regulate Flowering Time and Several Floral Homeotic Genes
Abstract
Floral transition should be strictly regulated because it is one of the most critical developmental processes in plants. Arabidopsis terminal flower 2 (tfl2) mutants show an early-flowering phenotype that is relatively insensitive to photoperiod, as well as several other pleiotropic phenotypes. We found that the early flowering of tfl2 is caused mainly by ectopic expression of the FLOWERING LOCUS T (FT) gene, a floral pathway integrator. Molecular cloning of TFL2 showed that it encodes a protein with homology to heterochromatin protein 1 (HP1) of animals and Swi6 of fission yeast. TFL2 protein localizes in subnuclear foci and expression of the TFL2 gene complemented yeast swi6(-) mutants. These results suggested that TFL2 might function as an HP1 in Arabidopsis: Gene expression analyses using DNA microarrays, however, did not show an increase in the expression of heterochromatin genes in tfl2 mutants but instead showed the upregulation of the floral homeotic genes APETALA3, PISTILLATA, AGAMOUS and SEPALLATA3. The pleiotropic phenotype of the tfl2 mutant could reflect the fact that TFL2 represses the expression of multiple genes. Our results demonstrate that despite its homology to HP1, TFL2 is involved in the repression of specific euchromatin genes and not heterochromatin genes in Arabidopsis.
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Activation Tagging of the Floral Inducer FT
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Self-citationControl of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
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Cited by
The genetic basis of flowering responses to seasonal cues
Andrés, F., & Coupland, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3291 · Cited by 1,538
The multifaceted roles of FLOWERING LOCUS T in plant development
PIN, P. A., & NILSSON, O. (2012) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.2012.02558.x · Cited by 384
Mylne, J. S., Barrett, L., Tessadori, F., Mesnage, S., Johnson, L., Bernatavichute, Y. V., Jacobsen, S. E., Fransz, P., & Dean, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507427103 · Cited by 304
Histone modifications and dynamic regulation of genome accessibility in plants
Pfluger, J., & Wagner, D. (2007) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2007.07.013 · Cited by 290
Metadata
- Authors
- Kotake, T., Takada, S., Nakahigashi, K., Ohto, M., & Goto, K.
- Venue
- Plant and Cell Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06-15
- Volume
- 44
- Issue
- 6
- Pages
- 555-564
- ISSN
- 0032-0781 (ISSN-L)
- 1471-9053
- OpenAlex
- W2136590766
- Cited by
- 257
- References
- 40
- FWCI
- 17.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kotake, T., Takada, S., Nakahigashi, K., Ohto, M., & Goto, K. (2003). Arabidopsis TERMINAL FLOWER 2 Gene Encodes a Heterochromatin Protein 1 Homolog and Represses both FLOWERING LOCUS T to Regulate Flowering Time and Several Floral Homeotic Genes. Plant and Cell Physiology. https://doi.org/10.1093/pcp/pcg091
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