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Cited by 290Genomics and Chromatin DynamicsPlant Molecular Biology ResearchEpigenetics and DNA Methylation

Histone modifications and dynamic regulation of genome accessibility in plants

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Pfluger, Jennifer, Wagner, Doris·2007·Current Opinion in Plant Biology
DOI 10.1016/j.pbi.2007.07.013PMC PMC2140274
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Abstract

In all eukaryotes chromatin physically restricts the accessibility of the genome to regulatory proteins such as transcription factors. Plant model systems have been instrumental in demonstrating that this restriction is dynamic and changes during development and in response to exogenous cues. Among the multiple epigenetic mechanisms that alter chromatin to regulate gene expression, histone modifications play a major role. Recent studies in Arabidopsis have provided the first genome-wide histone modification maps, revealed important biological roles for histone modifications, and advanced our understanding of stimulus-dependent changes in histone modifications.

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  • In the Arabidopsis genome, histone modifications such as H2BK143 ubiquitination, H3K4/H3K36/H3 methylation, and H3/H4 lysine acetylation are associated with gene activation, while H3K9/H3K27/H4K20 methylation and H4R3 dimethylation are associated with gene inactivation.

    “For example, it is well known that modifications such as the ubiquitination of H2BK143, mono-, di-, and trimethylation of H3K4, H3K36, and H3 and H4 lysine acetylation are associated, in Arabidopsis genome, with gene activation, while the mono-, di- and trimethylation of H3H9, H3K27, and H4K20, and the dimethylation of H4R3, are associated with gene inactivation [90,91,92,93]).”

    From Somaclonal Variation—Advantage or Disadvantage in Micropropagation of the Medicinal Plants (2023) · cites this paper as [90]

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Cited by

Sorted by citations

Authors
Pfluger, J., & Wagner, D.
Affiliations
University of Pennsylvania (US)
Corresponding author
Wagner, Doris
ORCID
Wagner, Doris
Venue
Current Opinion in Plant Biology
Publisher
Elsevier BV
Published
2007-12
Volume
10
Issue
6
Pages
645-652
ISSN
1369-5266 (ISSN-L)
DOI
10.1016/j.pbi.2007.07.013
PMC
PMC2140274
OpenAlex
W2162441687
Cited by
290
References
3
Citations by year
2026: 8 · 2025: 13 · 2024: 10 · 2023: 19 · 2022: 21 · 2021: 20 · 2020: 16 · 2019: 20 · 2018: 13 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 17 · 2012: 19
FWCI
1.36
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Current Opinion in Plant Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (R01 GM64650-01, F32GM076933, R01GM064650)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
histone modifications, chromatin accessibility, epigenetic regulation, gene expression regulation, Arabidopsis thaliana, plant development, transcription factor binding
MeSH terms
Histones, Arabidopsis, Gene Expression Regulation, Plant, Genome, Plant, Arabidopsis Proteins, Chromatin Assembly and Disassembly, Epigenesis, Genetic

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