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The design of a biochip: a self-assembling molecular-scale memory device
Abstract
A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies on the self-assembly of the nucleic acid junction system, which acts as the scaffolding for a molecular wire consisting of polyacetylene-like units. A molecular switch to control current is described which is based on the formation of a charge-transfer complex. A molecular-scale bit is presented which is based on oxidation-reduction potentials of metal atoms or clusters. The readable 'bit' which can be made of these components has a volume of 3 x 10(7) A3, and should operate at electronic speeds over short distances.
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Citations
Cited by
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
Self-citationSynthesis from DNA of a molecule with the connectivity of a cube
Chen, J., & Seeman, N. C. (1991) · Nature · doi:10.1038/350631a0 · Cited by 1,369
Self-citationSeeman, N. C. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-102244 · Cited by 992
Self-citationSelf-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates
Maune, H. T., Han, S.-P., Barish, R. D., Bockrath, M., III, W. A. G., Rothemund, P. W. K., & Winfree, E. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.311 · Cited by 622
Designed Two-Dimensional DNA Holliday Junction Arrays Visualized by Atomic Force Microscopy
Mao, C., Sun, W., & Seeman, N. C. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9900398 · Cited by 522
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Metadata
- Authors
- Robinson, B. H., & Seeman, N. C.
- Venue
- "Protein Engineering, Design and Selection"
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 1
- Issue
- 4
- Pages
- 295-300
- ISSN
- 0269-2139 (ISSN-L)
- 1741-0126
- 1741-0134
- OpenAlex
- W2059252348
- Cited by
- 180
- References
- 0
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The design of a biochip: a self-assembling molecular-scale memory device. https://app.cochat.ai/papers/10.1093/protein/1.4.295
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- Robinson, B. H., & Seeman, N. C. (1987). The design of a biochip: a self-assembling molecular-scale memory device. "Protein Engineering, Design and Selection". https://doi.org/10.1093/protein/1.4.295
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
