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The structure of signal peptides from bacterial lipoproteins
Abstract
Statistical analysis of lipoprotein and non-lipoprotein signal peptides reveals that the two classes differ significantly only in the region close to the signal peptidase cleavage site. This region is apolar and has the consensus sequence LA(G,A) decreases C in the lipoproteins, but is polar and has small, uncharged residues in positions -3 and -1 in the non-lipoproteins. A simple search for matches to the lipoprotein consensus cleavage site suffices to discriminate between the two groups with close to 100% reliability.
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Citations
Cited by
Expert system for predicting protein localization sites in gram‐negative bacteria
Nakai, K., & Kanehisa, M. (1991) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340110203 · Cited by 746
Hagman, K. E., Spratt, B. G., Balthazar, J. T., Pan, W., Judd, R. C., & Shafer, W. M. (1995) · Microbiology · doi:10.1099/13500872-141-3-611 · Cited by 368
Genetic and biochemical characterization of the oligopeptide transport system of Lactococcus lactis
Tynkkynen, S., Buist, G., Kunji, E., Kok, J., Poolman, B., Venema, G., & Haandrikman, A. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.23.7523-7532.1993 · Cited by 231
Stojiljkovic, I., & Hantke, K. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00465.x · Cited by 205
HOLCK, A., & NAeS, H. (1992) · Journal of General Microbiology · doi:10.1099/00221287-138-7-1353 · Cited by 106
Metadata
- Authors
- von Heijne, G.
- Venue
- "Protein Engineering, Design and Selection"
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 2
- Issue
- 7
- Pages
- 531-534
- ISSN
- 0269-2139 (ISSN-L)
- 1741-0126
- 1741-0134
- OpenAlex
- W2134759004
- Cited by
- 269
- References
- 0
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- von Heijne, G. (1989). The structure of signal peptides from bacterial lipoproteins. "Protein Engineering, Design and Selection". https://doi.org/10.1093/protein/2.7.531
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