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Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence
Abstract
Statistical analysis of 12 unstable and 32 stable proteins revealed that there are certain dipeptides, the occurrence of which is significantly different in the unstable proteins compared with those in the stable ones. Based on the impact of these dipeptides on the unstable proteins over the stable ones, a weight value of instability is assigned to each of the dipeptides. For a given protein the summation of these weight values normalized to the length of its sequence helps to distinguish between unstable and stable proteins. Results suggest that the in vivo instability of proteins is possibly determined by the order of certain amino acids in its sequence. An attempt is made to correlate metabolic stability of proteins with features of their primary sequence where weight values of instability for a protein of known sequence could thus be used as an index for predicting its stability characteristics.
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Cited by
Beverung, C. J., Radke, C. J., & Blanch, H. W. (1999) · Biophysical Chemistry · doi:10.1016/s0301-4622(99)00082-4 · Cited by 608
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Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates
Riba, A., Di Nanni, N., Mittal, N., Arhné, E., Schmidt, A., & Zavolan, M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817299116 · Cited by 209
Idicula‐Thomas, S., & Balaji, P. V. (2005) · Protein Science · doi:10.1110/ps.041009005 · Cited by 175
Begni, S., Popoli, M., Moraschi, S., Bignotti, S., Tura, G. B., & Gennarelli, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000987 · Cited by 71
Metadata
- Authors
- Guruprasad, K., Reddy, B. V. B., & Pandit, M. W.
- Venue
- "Protein Engineering, Design and Selection"
- Publisher
- Oxford University Press (OUP)
- Published
- 1990
- Volume
- 4
- Issue
- 2
- Pages
- 155-161
- ISSN
- 0269-2139 (ISSN-L)
- 1741-0126
- 1741-0134
- OpenAlex
- W2057021995
- Cited by
- 1,344
- References
- 0
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence. https://app.cochat.ai/papers/10.1093/protein/4.2.155
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- Guruprasad, K., Reddy, B. V. B., & Pandit, M. W. (1990). Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence. "Protein Engineering, Design and Selection". https://doi.org/10.1093/protein/4.2.155
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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