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Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease?
Abstract
Epidemiological studies indicate that fruit and vegetables are health-promoting and protective against disease, particularly cardiovascular disease and cancer. Possible plant nutrients providing this protection include antioxidants and dietary fibre. Clinical trials with antioxidant supplements give inconsistent results for protection against lung cancer in smokers, invasive cervical cancer, oesophageal and gastric cancers, colorectal polyps and coronary heart disease. The antioxidants used in trials may be contributing to a more complex system. Antioxidants have differing solubilities which partition across the phases of tissues, cells and macromolecular structures: water-soluble ascorbate, glutathione and urate; lipid-soluble tocopherols and carotenoids, and intermediatory-soluble flavonoids and hydroxycinnamic acids. The health protection provided by fruit and vegetables could arise through an integrated reductive environment delivered by plant antioxidants of differing solubility in each of the tissue, cellular and macromolecular phases.
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Cited by
Kurutas, E. B. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0186-5 · Cited by 2,152
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051
Lipophilic and Hydrophilic Antioxidant Capacities of Common Foods in the United States
Wu, X., Beecher, G. R., Holden, J. M., Haytowitz, D. B., Gebhardt, S. E., & Prior, R. L. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049696w · Cited by 1,747
Regulation of inflammation and redox signaling by dietary polyphenols
Rahman, I., Biswas, S. K., & Kirkham, P. A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.004 · Cited by 991
Youdim, K. A., & Joseph, J. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00510-4 · Cited by 435
Metadata
- Authors
- Eastwood, M. A.
- Venue
- QJM
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09-01
- Volume
- 92
- Issue
- 9
- Pages
- 527-530
- ISSN
- 0033-5622 (ISSN-L)
- 1460-2725
- 1460-2393
- OpenAlex
- W2156257098
- Cited by
- 217
- References
- 0
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
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