BONE GLA PROTEIN (BGP) LEVELS AND BONE TURNOVER IN RHEUMATOID ARTHRITIS
Abstract
Bone GLA protein (BGP) and other biochemical indices of bone turnover were measured in 42 female patients with rheumatoid arthritis (RA) and in a group of normal subjects matched for sex and age. Mean serum BGP concentrations were significantly higher in patients with active arthritis than in patients with mild activity (p less than 0.01) and controls (p less than 0.01). No significant difference was found in serum BGP levels and in other parameters of bone turnover when the patients were stratified according to functional class or duration of disease. There was a correlation between BGP and alkaline phosphatase levels only in RA patients with high activity of disease. Our data suggest an accelerated bone turnover in patients with active RA. We infer that in such patients the impairment of bone metabolism is a determinant of RA-associated osteopenia. Disease activity rather than functional impairment or duration of arthritis should be regarded as a factor in the bone loss of RA.
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In patients with chronic inflammatory diseases, serum levels of osteocalcin have been described as decreased, increased, or normal.
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [104]
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BONE MASS MEASUREMENT AND BONE METABOLISM IN RHEUMATOID ARTHRITIS: A REVIEW
Deodhar, A. A., & Woolf, A. D. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.4.309 · Cited by 234 · see citing works
“[68] found that those with active RA had 82% higher OC levels than patients with inactive RA and Marhoffer et al.”
BackgroundInteraction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
BackgroundShould we look for osteoporosis in patients with rheumatoid arthritis?
Lems, W. F., & Dijkmans, B. A. C. (1998) · Annals of the Rheumatic Diseases · doi:10.1136/ard.57.6.325 · Cited by 60 · see citing works
Bone turnover in non-steroid treated rheumatoid arthritis.
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Evidence of impaired cartilage/bone turnover in patients with active ankylosing spondylitis.
Marhoffer, W., Stracke, H. H. G., Masoud, I., et al. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.7.556 · Cited by 49 · see citing works
Serum osteocalcin and carboxyterminal propeptide of type I procollagen in rheumatoid arthritis.
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Increased levels of urinary collagen crosslinks in females with rheumatoid arthritis
Spector, T. D., James, I., Hall, G. M., Thompson, P. W., Perrett, D. I., & Hart, D. J. (1993) · Clinical Rheumatology · doi:10.1007/bf02231535 · Cited by 26 · see citing works
“Unfortunately, studies in RA have been disappointing, with raised (2) normal (3) and reduced (4) levels being reported in different studies possibly resulting in part from differences in disease activity and disease duration.”
BackgroundModifications of biochemical markers of bone and collagen turnover during corticosteroid therapy
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Bone Alkaline Phosphatase in Rheumatic Diseases
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“Studies have shown that the level of BGP is closely related to the severity of arthritis [25].”
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The usefulness of osteocalcin measurements in Malaysian patients with rheumatoid arthritis
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- Authors
- MAGARO, M., ALTOMONTE, L., MIRONE, L., ZOLI, A., & CORVINO, G.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- ORCID
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 28
- Issue
- 3
- Pages
- 207-211
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2106456153
- Cited by
- 18
- References
- 0
- Citations by year
- 2025: 1 · 2019: 1 · 2018: 2 · 2014: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- osteocalcin, bone turnover, rheumatoid arthritis, disease activity, osteopenia, bone loss, alkaline phosphatase, bone metabolism, serum biomarkers
- MeSH terms
- Adult, Alkaline Phosphatase, Arthritis, Rheumatoid, Bone and Bones, Calcium, Calcium-Binding Proteins, Fasting, Female, Humans, Middle Aged, Reference Values, Osteocalcin
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