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THE CHONDROCYTE: A CELL UNDER PRESSURE
Abstract
Mechanical load is an important regulator of chondrocyte metabolic activity. Changes in amplitude or frequency of the load can have a significant effect on the production of matrix macromolecules and of agents leading to cartilage breakdown. The composition of cartilage reflects the net response of the chondrocytes to the prevailing loading pattern, with cartilage proteoglycan content highest in heavily loaded regions and removal of load leading to cartilage thinning and proteoglycan loss. The mechanism of mechanotransduction is poorly understood; the chondrocytes appear to react to cartilage deformation and to the changes in hydrostatic pressure, extracellular ionic composition and streaming potentials induced by the load.
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Cited by
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Muir, H. (1995) · BioEssays · doi:10.1002/bies.950171208 · Cited by 454
Lubrication of Articular Cartilage
Jahn, S., Seror, J., & Klein, J. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-081514-123305 · Cited by 406
Brown, R. A., Prajapati, R., McGrouther, D. A., Yannas, I. V., & Eastwood, M. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199806)175:3<323::aid-jcp10>3.0.co;2-6 · Cited by 388
Smith, R. L., Rusk, S. F., Ellison, B. E., Wessells, P., Tsuchiya, K., Carter, D. R., Caler, W. E., Sandell, L. J., & Schurman, D. J. (1996) · Journal of Orthopaedic Research · doi:10.1002/jor.1100140110 · Cited by 273
Metadata
- Authors
- URBAN, J. P. G.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994
- Volume
- 33
- Issue
- 10
- Pages
- 901-908
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2092868973
- Cited by
- 429
- References
- 0
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- URBAN, J. P. G. (1994). THE CHONDROCYTE: A CELL UNDER PRESSURE. Rheumatology. https://doi.org/10.1093/rheumatology/33.10.901
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
