The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules
Abstract
Chondrocytes are specialised cells which produce and maintain the extracellular matrix of cartilage, a tissue that is resilient and pliant. In vivo, it has to withstand very high compressive loads, and that is explicable in terms of the physico‐chemical properties of cartilage‐specific macromolecules and with the movement of water and ions within the matrix. The functions of the cartilage‐specific collagens, aggrecan (a hydrophilic proteoglycan) and hyaluronan are discussed within this context. The structures of cartilage collagens and proteoglycans and their genes are known and a number of informative mutations have been identified. In particular, collagen fibrillogenesis is a complex process which can be altered by mutations whose effects fit what is known about collagen molecular structural functions. In other instances, mutations have indicated new functions for particular molecular domains. As cartilage provides the template for the developing skeleton, mutations in genes for cartilage‐specific proteins often produce developmental abnormalities. The search for mutations amongst such genes in heritable disorders is being actively pursued by many groups, although mutation and phenotype are not always well correlated, probably because of compensatory mechanisms. The special nature of the chondrocyte is stressed in connection with its cell involvement in osteoarthritis, the most widespread disease of diarthrodial joints.
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Cites
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Proteoglycans: many forms and many functions
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The specific interaction of hyaluronic acid with cartilage proteoglycans.
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Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads
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Self-citation
Cited by
The Basic Science of Articular Cartilage: Structure, Composition, and Function
Sophia Fox, A. J., Bedi, A., & Rodeo, S. A. (2009) · Sports Health: A Multidisciplinary Approach · doi:10.1177/1941738109350438 · Cited by 2,774
Targeting the tumour stroma to improve cancer therapy
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Direct Human Cartilage Repair Using Three-Dimensional Bioprinting Technology
Cui, X., Breitenkamp, K., Finn, M. G., Lotz, M., & D'Lima, D. D. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0543 · Cited by 686
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Yang, J., Zhang, Y. S., Yue, K., & Khademhosseini, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.036 · Cited by 652
Quantitative structural organization of normal adult human articular cartilage
Hunziker, E. B., Quinn, T. M., & Häuselmann, H.-J. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2002.0814 · Cited by 502
Metadata
- Authors
- Muir, H.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 17
- Issue
- 12
- Pages
- 1039-1048
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2122883560
- Cited by
- 454
- References
- 47
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Muir, H. (1995). The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. BioEssays. https://doi.org/10.1002/bies.950171208
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
