Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis
Abstract
Dendritic cells (DCs) are a cluster of heterogeneous antigen-presenting cells that play a pivotal role in both innate and adaptive immune responses. Rare reports have discussed their role in OA immunopathogenesis. Recently, DCs derived from the synovial fluid of OA mice were shown to have increased expression of toll-like receptors. Moreover, from in vitro studies it was concluded that DCs derived from OA patients had secreted high levels of inflammatory cytokines. Likewise, a significant increase in CD123+BDCA-2 plasmacytoid DCs has been observed in the synovial fluid of OA patients. Furthermore, DCs have a peripheral tolerance potential and can become regulatory under specific circumstances. This could be exploited as a promising tool to eliminate immunoinflammatory manifestations in OA disease. In this review, the potential roles DCs could play in OA pathogenesis have been described. In addition, suggestions for the development of new immunotherapeutic strategies involving intra-articular injections of tolerogenic plasmacytoid DCs for treating OA inflammations have been made.
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The maturation and activation of both immature and mature dendritic cells are affected by mesenchymal stem cells.
“The maturation and activation of both immature and mature dendritic cells (DC) are affected by MSCs [83].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [83]
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- Authors
- Alahdal, M., Zhang, H., Huang, R., Sun, W., Deng, Z., Duan, L., Ouyang, H., & Wang, D.
- Affiliations
- Shenzhen Second People's Hospital (CN)
- Zhejiang University (CN)
- Southern University of Science and Technology (CN)
- Corresponding author
- Wang, Daping
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-29
- Volume
- 60
- Issue
- 2
- Pages
- 507-517
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W3109571862
- Cited by
- 50
- References
- 93
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 3
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Science and Technology Cooperation Project of Guangdong Province 2019, China (1035043)
- National Natural Science Foundation of China (81772394, 81972116, 81972085)
- Key Program of Natural Science Foundation of Guangdong Province (2018B0303110003)
- Shenzhen Peacock Project (KQTD20170331100838136)
- Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties (SZGSP007)
- International Science and Technology Cooperation Project of Guangdong Province 2019 (1035043)
- Shenzhen Science and Technology Projects (JCYJ20170817172023838, JCYJ20170306092215436, JCYJ20170412150609690, JCYJ20170413161649437, JCYJ20170413161800287)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- dendritic cells, osteoarthritis, immunomodulation, plasmacytoid dendritic cells, synovial fluid, Toll-like receptors, inflammatory cytokines, peripheral tolerance, regulatory dendritic cells, intra-articular injection, immunotherapy, immunopathogenesis
- MeSH terms
- Animals, Dendritic Cells, Humans, Osteoarthritis, Cytokines, Disease Management, Immunomodulation
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