The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
Abstract
OBJECTIVES: Various autoantibodies are detected in the sera of PM/DM patients. Some of them are specific to PM/DM patients and closely associated with clinical manifestations of the diseases. Recently, the anti-CADM-140 antibody was reported to be found specifically in clinically amyopathic DM (C-ADM) patients and to be associated with acute interstitial lung disease (ILD). We assessed the clinical significance of the anti-CADM-140 antibody and then investigated the autoantigen recognized by the anti-CADM-140 antibody. METHODS: Autoantibodies were screened in 192 patients with various CTDs and 21 healthy controls using immunoprecipitation with [(35)S]methionine-labelled HeLa cells. Immunoabsorbent column chromatography was used to purify an autoantigen that was subsequently subjected to peptide mass fingerprinting. RESULTS: The anti-CADM-140 antibody was revealed to be specific to DM. Most of the anti-CADM-140-positive patients were C-ADM although some of them showed apparent myositis. The anti-CADM-140-positive patients frequently showed hyperferritinaemia and acute progressive ILD with poor prognosis. The anti-CADM-140 antibody was shown to recognize IFN induced with helicase C domain protein 1 (IFIH1), also known as the melanoma differentiation-associated gene 5 (MDA5), which is one of the RIG-I-like receptors and plays a role in innate immune responses. CONCLUSION: The anti-CADM-140 antibody was a marker of DM and intractable ILD and recognized IFIH1/MDA5, which is involved in innate immunity. These findings may give a new insight into the pathogenesis of DM.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,385
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
Lerner, M. R., & Steitz, J. A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5495 · Cited by 1,156
Sato, S., Hirakata, M., Kuwana, M., Suwa, A., Inada, S., Mimori, T., Nishikawa, T., Oddis, C. V., & Ikeda, Y. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21023 · Cited by 747
Self-citationKang, D.-C., Gopalkrishnan, R. V., Wu, Q., Jankowsky, E., Pyle, A. M., & Fisher, P. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022637199 · Cited by 651
Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis
Allen, C. E., Yu, X., Kozinetz, C. A., & McClain, K. L. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21423 · Cited by 634
Sato, S., Hoshino, K., Satoh, T., Fujita, T., Kawakami, Y., Fujita, T., & Kuwana, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24621 · Cited by 604
Gerami, P., Schope, J. M., McDonald, L., Walling, H. W., & Sontheimer, R. D. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.10.041 · Cited by 455
Mimori, T., Hardin, J. A., & Steitz, J. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35929-x · Cited by 326
Self-citation
Cited by
Immune Signaling by RIG-I-like Receptors
Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875
Fiorentino, D., Chung, L., Zwerner, J., Rosen, A., & Casciola-Rosen, L. (2011) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2010.09.016 · Cited by 554
Satoh, M., Tanaka, S., Ceribelli, A., Calise, S. J., & Chan, E. K. L. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8510-y · Cited by 420
Tsuji, H., Nakashima, R., Hosono, Y., Imura, Y., Yagita, M., Yoshifuji, H., Hirata, S., Nojima, T., Sugiyama, E., Hatta, K., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41105 · Cited by 357
Self-citationGono, T., Sato, S., Kawaguchi, Y., Kuwana, M., Hanaoka, M., Katsumata, Y., Takagi, K., Baba, S., Okamoto, Y., Ota, Y., et al. (2012) · Rheumatology · doi:10.1093/rheumatology/kes102 · Cited by 339
Metadata
- Authors
- Nakashima, R., Imura, Y., Kobayashi, S., Yukawa, N., Yoshifuji, H., Nojima, T., Kawabata, D., Ohmura, K., Usui, T., Fujii, T., Okawa, K., & Mimori, T.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-16
- Volume
- 49
- Issue
- 3
- Pages
- 433-440
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2134292259
- Cited by
- 334
- References
- 24
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. https://app.cochat.ai/papers/10.1093/rheumatology/kep375
- The paper
- Nakashima, R., Imura, Y., Kobayashi, S., Yukawa, N., Yoshifuji, H., Nojima, T., Kawabata, D., Ohmura, K., Usui, T., Fujii, T., Okawa, K., & Mimori, T. (2010). The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. Rheumatology. https://doi.org/10.1093/rheumatology/kep375
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
