Immune Signaling by RIG-I-like Receptors

Lysine acetylation targets protein complexes and co-regulates major cellular functions

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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HOW CELLS RESPOND TO INTERFERONS

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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5'-Triphosphate RNA Is the Ligand for RIG-I

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates

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NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

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IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

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Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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The roles of TLRs, RLRs and NLRs in pathogen recognition

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

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IL-28, IL-29 and their class II cytokine receptor IL-28R

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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

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Cell Type-Specific Involvement of RIG-I in Antiviral Response

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RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185 · see citing works

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

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I nterleukin -10 and R elated C ytokines and R eceptors

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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

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Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

Jego, G., Palucka, A. K., Blanck, J.-P., Chalouni, C., Pascual, V., & Banchereau, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00208-5 · Cited by 1,067 · see citing works

Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7

Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049 · see citing works

Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo

Bon, A. L., Schiavoni, G., D’Agostino, G., Gresser, I., Belardelli, F., & Tough, D. F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00126-1 · Cited by 973 · see citing works

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

Kolumam, G. A., Thomas, S., Thompson, L. J., Sprent, J., & Murali‐Krishna, K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050821 · Cited by 967 · see citing works

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Häcker, G. A., et al. (2005) · Nature · doi:10.1038/nature04369 · Cited by 962 · see citing works

Rare Variants of <i>IFIH1</i> , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

Nejentsev, S., Walker, N., Riches, D., Egholm, M., & Todd, J. A. (2009) · Science · doi:10.1126/science.1167728 · Cited by 958 · see citing works

Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

Sumpter, R., Loo, Y., Foy, E. M., Li, K., Yoneyama, M., Fujita, T., Lemon, S. M., & Gale, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2689-2699.2005 · Cited by 900 · see citing works

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892 · see citing works

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zarnegar, B. J., Perry, A. K., & Cheng, G. (2005) · Nature · doi:10.1038/nature04374 · Cited by 881 · see citing works

Peroxisomes are signaling platforms for antiviral innate immunity

Dixit, E., Boulant, S., Zhang, Y.-J., Lee, A. S., Odendall, C., Shum, B. O. V., Hacohen, N., Chen, Z.-J. J., Whelan, S. P. J., Fransen, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.018 · Cited by 848 · see citing works

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Schlee, M., Roth, A. H. F. J., Hornung, V., Hagmann, C. A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.008 · Cited by 792 · see citing works

Type I Interferons Keep Activated T Cells Alive

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Autoantibodies to a 140‐kd polypeptide, CADM‐140, in Japanese patients with clinically amyopathic dermatomyositis

Sato, S., Hirakata, M., Kuwana, M., Suwa, A., Inada, S., Mimori, T., Nishikawa, T., Oddis, C. V., & Ikeda, Y. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21023 · Cited by 748 · see citing works

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Saito, T., Owen, D. M., Jiang, F., Marcotrigiano, J., & Gale, M. (2008) · Nature · doi:10.1038/nature07106 · Cited by 745 · see citing works

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

Saito, T., Hirai, R., Loo, Y., Owen, D. M., Johnson, C., Sinha, S. C., Akira, S., Fujita, T., & Gale, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606699104 · Cited by 743 · see citing works

LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., & Takeuchi, O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912986107 · Cited by 697 · see citing works

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

Smyth, D. J., Cooper, J. D., Bailey, R., Field, S., Burren, O. S., Smink, L. J., Guja, C., Ionescu-Tirgoviste, C., Widmer, B., Dunger, D. B., et al. (2006) · Nature Genetics · doi:10.1038/ng1800 · Cited by 688 · see citing works

Small self-RNA generated by RNase L amplifies antiviral innate immunity

Malathi, K., Dong, B., Gale, M., & Silverman, R. H. (2007) · Nature · doi:10.1038/nature06042 · Cited by 636 · see citing works

Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation

Curtsinger, J., Valenzuela, J. O., Agarwal, P., Lins, D. C., & Mescher, M. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4465 · Cited by 633 · see citing works

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., & Chen, Z. J. (2010) · Cell · doi:10.1016/j.cell.2010.03.029 · Cited by 613 · see citing works

RNA helicase encoded by melanoma differentiation–associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease

Sato, S., Hoshino, K., Satoh, T., Fujita, T., Kawakami, Y., Fujita, T., & Kuwana, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24621 · Cited by 601 · see citing works

Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo

Ank, N., West, H., Bartholdy, C., Eriksson, K., Thomsen, A. R., & Paludan, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.9.4501-4509.2006 · Cited by 598 · see citing works

NLRX1 is a regulator of mitochondrial antiviral immunity

Moore, C. B., Bergstralh, D. T., Duncan, J. A., Lei, Y. L., Morrison, T. E., Zimmermann, A. G., Accavitti-Loper, M. A., Madden, V. J., Sun, L., Ye, Z., et al. (2008) · Nature · doi:10.1038/nature06501 · Cited by 586 · see citing works

Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

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The Atg5–Atg12 conjugate associates with innate antiviral immune responses

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Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

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Essential role of IPS-1 in innate immune responses against RNA viruses

Kumar, H., Kawai, T., Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K. J., Takeuchi, O., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060792 · Cited by 503 · see citing works

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K. D., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K., Krug, A., & Hopfner, K. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.10.032 · Cited by 495 · see citing works

Viral infection and Toll‐like receptor agonists induce a differential expression of type I and λ interferons in human plasmacytoid and monocyte‐derived dendritic cells

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Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

Arimoto, K., Takahashi, H., Hishiki, T., Konishi, H., Fujita, T., & Shimotohno, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611551104 · Cited by 472 · see citing works

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

Pichlmair, A., Schulz, O., Tan, C.-P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., & Sousa, C. R. E. (2009) · Journal of Virology · doi:10.1128/jvi.00770-09 · Cited by 469 · see citing works

A Deubiquitinase That Regulates Type I Interferon Production

Kayagaki, N., Phung, Q. T., Chan, S. B., Chaudhari, R., Quan, C., O’Rourke, K. M., Eby, M. T., Pietras, E. M., Cheng, G., Bazán, J. F., et al. (2007) · Science · doi:10.1126/science.1145918 · Cited by 452 · see citing works

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

Cui, J., Zhu, L., Xia, X., Wang, H. Y., Legras, X. D., Hong, J. K., Ji, J., Shen, P., Zheng, S. S., Chen, Z. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.040 · Cited by 449 · see citing works

Interferon-Lambda: A New Addition to an Old Family

Donnelly, R. P., & Kotenko, S. V. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0078 · Cited by 427 · see citing works

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

Baum, A., Sachidanandam, R., & García‐Sastre, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005077107 · Cited by 424 · see citing works

Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses

Venkataraman, T., Valdes, M., Elsby, R., Kakuta, S., Cáceres, G., Saijo, S., Iwakura, Y., & Barber, G. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6444 · Cited by 400 · see citing works

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Diabetologia · doi:10.1007/s00125-009-1276-0 · Cited by 384 · see citing works

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

Marques, J. T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M. A., & Williams, B. R. G. (2006) · Nature Biotechnology · doi:10.1038/nbt1205 · Cited by 380 · see citing works

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

Daffis, S., Samuel, M. A., Suthar, M. S., Gale, M., & Diamond, M. (2008) · Journal of Virology · doi:10.1128/jvi.00935-08 · Cited by 359 · see citing works

Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism

Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608618200 · Cited by 354 · see citing works

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

Oshiumi, H., Matsumoto, M., Hatakeyama, S., & Seya, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804259200 · Cited by 353 · see citing works

The tumour suppressor CYLD is a negative regulator of RIG‐I‐mediated antiviral response

Friedman, C. S., O’Donnell, M. A., Legarda, D., Ng, A., Cardenas, W. B., Yount, J. S., Moran, T. M., Basler, C. F., Komuro, A., Horvath, C. M., et al. (2008) · EMBO Reports · doi:10.1038/embor.2008.136 · Cited by 334 · see citing works

The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody

Nakashima, R., Imura, Y., Kobayashi, S., Yukawa, N., Yoshifuji, H., Nojima, T., Kawabata, D., Ohmura, K., Usui, T., Fujii, T., et al. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep375 · Cited by 334 · see citing works

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

Habjan, M., Andersson, I., Klingström, J., Schümann, M., Arnold, M., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U., Mühlberger, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002032 · Cited by 331 · see citing works

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

Fredericksen, B. L., Keller, B. C., Fornek, J. L., Katze, M. G., & Gale, M. (2007) · Journal of Virology · doi:10.1128/jvi.01305-07 · Cited by 328 · see citing works

Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis

Gono, T., Kawaguchi, Y., Satoh, T., Kuwana, M., Katsumata, Y., Takagi, K., Masuda, I., Tochimoto, A., Baba, S., Okamoto, Y., et al. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq149 · Cited by 319 · see citing works

The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways

Zhao, T., Yang, L., Sun, Q., Arguello, M., Ballard, D. W., Hiscott, J. B., & Lin, R. (2007) · Nature Immunology · doi:10.1038/ni1465 · Cited by 317 · see citing works

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

Castanier, C., Garcin, D., Vazquez, A., & Arnoult, D. (2010) · The EMBO Reports · doi:10.1038/embor.2009.258 · Cited by 316 · see citing works

EB virus‐encoded RNAs are recognized by RIG‐I and activate signaling to induce type I IFN

Samanta, M., Iwakiri, D., Kanda, T., Imaizumi, T., & Takada, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601314 · Cited by 313 · see citing works

Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T., & Akira, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4711 · Cited by 309 · see citing works

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Michallet, M., Meylan, E., Ermolaeva, M., Vázquez, J., Rebsamen, M., Curran, J. A., Poeck, H., Bscheider, M., Hartmann, G., König, M. F., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.013 · Cited by 304 · see citing works

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