The levels of the adipokines adipsin and leptin are associated with knee osteoarthritis progression as assessed by MRI and incidence of total knee replacement in symptomatic osteoarthritis patients: a post hoc analysis
Abstract
OBJECTIVE: Limited studies have explored the association between adipokines and knee OA structural progression using quantitative MRI (qMRI), and very few have included total knee replacement (TKR) as a disease outcome. The objective of this study was to compare serum levels of five adipokines to cartilage volume loss (CVL) and investigate their predictive value for TKR. METHODS: The according-to-protocol population (n = 138) of a knee OA trial was used. Serum levels of adipsin (complement factor D), leptin, adiponectin, resistin and serpin E1, and cartilage volume were determined at baseline and 24 months with specific ELISAs and qMRI, respectively. Study knee TKR incidence up to 4 years post-trial was also assessed. RESULTS: Greater baseline values of adipsin and leptin correlated with increased CVL in the global knee and medial femur (P ⩽ 0.032) and of adipsin in the lateral compartment and femur (P ⩽ 0.028). Adiponectin showed an inverse correlation in the medial compartment and femur (P ⩽ 0.027). Resistin and serpin E1 were not associated with CVL. Multivariate analyses revealed that patients in the highest tertile at baseline of adipsin presented a greater odds ratio of CVL in the lateral compartment and femur (⩾2.87; P ⩽ 0.011), and those in the highest tertile of leptin in the medial compartment (2.78; P = 0.038). Most clinically relevant, patients in the highest tertile of adipsin or leptin at baseline had significantly greater incidence of TKR (P = 0.027). CONCLUSION: Data demonstrate that both adipsin and leptin predict greater CVL over time in the lateral and medial compartment, respectively. Importantly, this study also demonstrates that higher baseline levels of adipsin or leptin are associated with higher incidence of TKR.
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CFD is involved in pathophysiological mechanisms of osteoarthritis and is considered a potential predictive biomarker of joint pain in patients with hip and knee osteoarthritis.
“In line with this finding, patients’ cells also showed increased mRNA levels of complement factor D (CFD), a component of the alternative complement pathway [147], which is involved in pathophysiological mechanisms of osteoarthritis and is considered as a potential predictive biomarker of joint pain in patients with hip and knee osteoarthritis [148,149,150].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [149]
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- Authors
- Martel-Pelletier, J., Raynauld, J.-P., Dorais, M., Abram, F., & Pelletier, J.-P.
- Affiliations
- Université de Montréal (CA)
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-12-11
- Volume
- 55
- Issue
- 4
- Pages
- 680-688
- ISSN
- 1462-0324 (ISSN-L)
- 1462-0332
- OpenAlex
- W2270478562
- Cited by
- 68
- References
- 50
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 11 · 2016: 6
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lara D. Veeken (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- knee osteoarthritis, adipokines, adipsin, leptin, adiponectin, resistin, SERPINE1, cartilage volume loss, total knee arthroplasty, disease progression, serum biomarkers, quantitative MRI
- MeSH terms
- Aged, Cartilage, Articular, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Complement Factor D, Severity of Illness Index, Biomarkers, Body Mass Index, Disease Progression, Arthroplasty, Replacement, Knee, Osteoarthritis, Knee, Leptin
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